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Page 1
First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents.
Alencar N, Sola I, Linares M, Juárez-Jiménez J, Pont C, Viayna A, Vílchez D, Sampedro C, Abad P, Pérez-Benavente S, Lameira J, Bautista JM, Muñoz-Torrero D, Luque FJ. Alencar N, et al. Among authors: pont c. Eur J Med Chem. 2018 Feb 25;146:108-122. doi: 10.1016/j.ejmech.2018.01.044. Epub 2018 Feb 4. Eur J Med Chem. 2018. PMID: 29407943
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.
Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: pont c. Future Med Chem. 2017 Jun;9(10):965-981. doi: 10.4155/fmc-2017-0049. Epub 2017 Jun 20. Future Med Chem. 2017. PMID: 28632395
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: pont c. Eur J Med Chem. 2019 Oct 15;180:613-626. doi: 10.1016/j.ejmech.2019.07.051. Epub 2019 Jul 17. Eur J Med Chem. 2019. PMID: 31351393 Free article.
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallàs M, Luque FJ, Muñoz-Torrero D. Pont C, et al. Eur J Med Chem. 2021 Dec 5;225:113779. doi: 10.1016/j.ejmech.2021.113779. Epub 2021 Aug 16. Eur J Med Chem. 2021. PMID: 34418785 Free article.
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. Codony S, et al. Among authors: pont c. J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271276 Free PMC article.
A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet.
Espinosa-Jiménez T, Cano A, Sánchez-López E, Olloquequi J, Folch J, Bulló M, Verdaguer E, Auladell C, Pont C, Muñoz-Torrero D, Parcerisas A, Camins A, Ettcheto M. Espinosa-Jiménez T, et al. Among authors: pont c. Cell Biosci. 2023 Mar 9;13(1):52. doi: 10.1186/s13578-023-01000-y. Cell Biosci. 2023. PMID: 36895036 Free PMC article.
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties.
Pont C, Sampietro A, Pérez-Areales FJ, Cristiano N, Albalat A, Pérez B, Bartolini M, De Simone A, Andrisano V, Barenys M, Teixidó E, Sabaté R, Loza MI, Brea J, Muñoz-Torrero D. Pont C, et al. Pharmaceutics. 2024 Jul 25;16(8):982. doi: 10.3390/pharmaceutics16080982. Pharmaceutics. 2024. PMID: 39204327 Free PMC article.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Thomas M, Brand S, De Rycker M, Zuccotto F, Lukac I, Dodd PG, Ko EJ, Manthri S, McGonagle K, Osuna-Cabello M, Riley J, Pont C, Simeons F, Stojanovski L, Thomas J, Thompson S, Viayna E, Fiandor JM, Martin J, Wyatt PG, Miles TJ, Read KD, Marco M, Gilbert IH. Thomas M, et al. Among authors: pont c. J Med Chem. 2021 May 13;64(9):5905-5930. doi: 10.1021/acs.jmedchem.1c00047. Epub 2021 Apr 27. J Med Chem. 2021. PMID: 33904304 Free PMC article.
84 results