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Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.
Nat Metab. 2023 Dec;5(12):2169-2183. doi: 10.1038/s42255-023-00932-6. Epub 2023 Nov 30.
Nat Metab. 2023.
PMID: 38036771
Free PMC article.
Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR.
Shoop WK, Gorsuch CL, Bacman SR, Moraes CT.
Shoop WK, et al. Among authors: gorsuch cl.
J Biol Chem. 2022 Nov;298(11):102574. doi: 10.1016/j.jbc.2022.102574. Epub 2022 Oct 6.
J Biol Chem. 2022.
PMID: 36209825
Free PMC article.
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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Gorsuch CL, Nemec P, Yu M, Xu S, Han D, Smith J, Lape J, van Buuren N, Ramirez R, Muench RC, Holdorf MM, Feierbach B, Falls G, Holt J, Shoop W, Sevigny E, Karriker F, Brown RV, Joshi A, Goodwin T, Tam YK, Lin PJC, Semple SC, Leatherbury N, Delaney Iv WE, Jantz D, Rhoden Smith A.
Gorsuch CL, et al.
Mol Ther. 2022 Sep 7;30(9):2909-2922. doi: 10.1016/j.ymthe.2022.05.013. Epub 2022 May 16.
Mol Ther. 2022.
PMID: 35581938
Free PMC article.
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RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.
Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT.
Hawk MA, et al. Among authors: gorsuch cl.
Nat Cell Biol. 2018 Mar;20(3):272-284. doi: 10.1038/s41556-018-0034-2. Epub 2018 Feb 19.
Nat Cell Biol. 2018.
PMID: 29459781
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