Hashimoto R - Search Results

1

Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein.

Masuda Y, Yamaguchi S, Suzuki C, Aburatani T, Nagano Y, Miyauchi R, Suzuki E, Yamamura N, Nagatomo K, Ishihara H, Okuno K, Nara F, Matschiner G, Hashimoto R, Takahashi T, Nishizawa T. Masuda Y, et al. Among authors: hashimoto r. J Pharmacol Exp Ther. 2018 May;365(2):368-378. doi: 10.1124/jpet.117.246652. Epub 2018 Feb 20. J Pharmacol Exp Ther. 2018. PMID: 29463608

2

Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities.

Shinozaki N, Hashimoto R, Fukui K, Uchiyama S. Shinozaki N, et al. Among authors: hashimoto r. Sci Rep. 2017 Jul 19;7(1):5794. doi: 10.1038/s41598-017-06277-x. Sci Rep. 2017. PMID: 28725057 Free PMC article.

3

A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases.

Nishimiya D, Kawaguchi Y, Kodama S, Nasu H, Yano H, Yamaguchi A, Tamura M, Hashimoto R. Nishimiya D, et al. Among authors: hashimoto r. Sci Rep. 2019 Aug 7;9(1):11436. doi: 10.1038/s41598-019-47615-5. Sci Rep. 2019. PMID: 31391482 Free PMC article.

4

Physicochemical improvement of rabbit derived single-domain antibodies by substitutions with amino acids conserved in camelid antibodies.

Shinozaki N, Hashimoto R, Noda M, Uchiyama S. Shinozaki N, et al. Among authors: hashimoto r. J Biosci Bioeng. 2018 Jun;125(6):654-661. doi: 10.1016/j.jbiosc.2018.01.006. Epub 2018 Feb 15. J Biosci Bioeng. 2018. PMID: 29398547

5

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library.

Yano H, Nishimiya D, Kawaguchi Y, Tamura M, Hashimoto R. Yano H, et al. Among authors: hashimoto r. PLoS One. 2020 Dec 29;15(12):e0244656. doi: 10.1371/journal.pone.0244656. eCollection 2020. PLoS One. 2020. PMID: 33373399 Free PMC article.

6

Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate.

Ohtoyo M, Machinaga N, Inoue R, Hagihara K, Yuita H, Tamura M, Hashimoto R, Chiba J, Muro F, Watanabe J, Kobayashi Y, Abe K, Kita Y, Nagasaki M, Shimozato T. Ohtoyo M, et al. Among authors: hashimoto r. Cell Chem Biol. 2016 May 19;23(5):555-560. doi: 10.1016/j.chembiol.2016.04.007. Epub 2016 May 12. Cell Chem Biol. 2016. PMID: 27185637 Free article.

7

Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.

Ohtoyo M, Tamura M, Machinaga N, Muro F, Hashimoto R. Ohtoyo M, et al. Among authors: hashimoto r. Mol Cell Biochem. 2015 Feb;400(1-2):125-33. doi: 10.1007/s11010-014-2268-z. Epub 2014 Nov 9. Mol Cell Biochem. 2015. PMID: 25381637

8

Fibronectin promotes proplatelet formation in the human megakaryocytic cell line UT-7/TPO.

Kawaguchi T, Hatano R, Yamaguchi K, Nawa K, Hashimoto R, Yokota H. Kawaguchi T, et al. Among authors: hashimoto r. Cell Biol Int. 2012 Jan;36(1):39-45. doi: 10.1042/CBI20110383. Cell Biol Int. 2012. PMID: 21970435

9

Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels.

Ohtoyo M, Tamura M, Machinaga N, Muro F, Hashimoto R. Ohtoyo M, et al. Among authors: hashimoto r. Lipids. 2016 Oct;51(10):1207-1216. doi: 10.1007/s11745-016-4187-0. Epub 2016 Sep 2. Lipids. 2016. PMID: 27585475

10

The human megakaryocytic cell line UT-7/TPO responds to platelet agonists with intracellular Ca2+ elevation and P-selectin expression.

Kawaguchi T, Hashimoto R, Nawa K, Yokota H. Kawaguchi T, et al. Among authors: hashimoto r. Cell Biol Int. 2011 May;35(5):537-43. doi: 10.1042/CBI20100636. Cell Biol Int. 2011. PMID: 21143192

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