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Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.
Gour N, Lajoie S, Smole U, White M, Hu D, Goddard P, Huntsman S, Eng C, Mak A, Oh S, Kim JH, Sharma A, Plante S, Salem IH, Resch Y, Xiao X, Yao N, Singh A, Vrtala S, Chakir J, Burchard EG, Lane AP, Wills-Karp M. Gour N, et al. Among authors: smole u. Sci Immunol. 2018 Feb 23;3(20):eaam9841. doi: 10.1126/sciimmunol.aam9841. Sci Immunol. 2018. PMID: 29475849 Free PMC article.
C3a is required for ILC2 function in allergic airway inflammation.
Gour N, Smole U, Yong HM, Lewkowich IP, Yao N, Singh A, Gabrielson E, Wills-Karp M, Lajoie S. Gour N, et al. Among authors: smole u. Mucosal Immunol. 2018 Nov;11(6):1653-1662. doi: 10.1038/s41385-018-0064-x. Epub 2018 Aug 13. Mucosal Immunol. 2018. PMID: 30104625 Free PMC article.
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.
Smole U, Gour N, Phelan J, Hofer G, Köhler C, Kratzer B, Tauber PA, Xiao X, Yao N, Dvorak J, Caraballo L, Puerta L, Rosskopf S, Chakir J, Malle E, Lane AP, Pickl WF, Lajoie S, Wills-Karp M. Smole U, et al. Nat Immunol. 2020 Jul;21(7):756-765. doi: 10.1038/s41590-020-0698-1. Epub 2020 Jun 22. Nat Immunol. 2020. PMID: 32572240 Free PMC article.
The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg.
Tauber PA, Kratzer B, Schatzlmaier P, Smole U, Köhler C, Rausch L, Kranich J, Trapin D, Neunkirchner A, Zabel M, Jutz S, Steinberger P, Gadermaier G, Brocker T, Stockinger H, Derdak S, Pickl WF. Tauber PA, et al. Among authors: smole u. Front Immunol. 2023 Apr 6;14:1094694. doi: 10.3389/fimmu.2023.1094694. eCollection 2023. Front Immunol. 2023. PMID: 37090735 Free PMC article.
Murine models for mucosal tolerance in allergy.
Smole U, Schabussova I, Pickl WF, Wiedermann U. Smole U, et al. Semin Immunol. 2017 Apr;30:12-27. doi: 10.1016/j.smim.2017.07.007. Epub 2017 Aug 12. Semin Immunol. 2017. PMID: 28807539 Free PMC article. Review.
26 results