Hughes D - Search Results

1

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.

Hughes D, Mallucci GR. Hughes D, et al. FEBS J. 2019 Jan;286(2):342-355. doi: 10.1111/febs.14422. Epub 2018 Mar 11. FEBS J. 2019. PMID: 29476642 Free article. Review.

2

Fine-tuning PERK signaling for neuroprotection.

Halliday M, Hughes D, Mallucci GR. Halliday M, et al. Among authors: hughes d. J Neurochem. 2017 Sep;142(6):812-826. doi: 10.1111/jnc.14112. Epub 2017 Aug 8. J Neurochem. 2017. PMID: 28643372 Free PMC article. Review.

3

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.

Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Smith HL, et al. Neuron. 2020 Mar 4;105(5):855-866.e5. doi: 10.1016/j.neuron.2019.12.014. Epub 2020 Jan 7. Neuron. 2020. PMID: 31924446 Free PMC article.

4

Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice.

Hughes DT, Halliday M, Smith HL, Verity NC, Molloy C, Radford H, Butcher AJ, Mallucci GR. Hughes DT, et al. Sci Signal. 2020 Aug 11;13(644):eabb4749. doi: 10.1126/scisignal.abb4749. Sci Signal. 2020. PMID: 32788341

5

ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo.

Preußner M, Smith HL, Hughes D, Zhang M, Emmerichs AK, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F. Preußner M, et al. Among authors: hughes d. EMBO Mol Med. 2023 May 8;15(5):e17157. doi: 10.15252/emmm.202217157. Epub 2023 Mar 22. EMBO Mol Med. 2023. PMID: 36946385 Free PMC article.

6

PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress.

Brar KK, Hughes DT, Morris JL, Subramanian K, Krishna S, Gao F, Rieder LS, Uhrig S, Freeman J, Smith HL, Jukes-Jones R, Avezov E, Nunnari J, Prudent J, Butcher AJ, Mallucci GR. Brar KK, et al. Science. 2024 Aug 30;385(6712):eadp7114. doi: 10.1126/science.adp7114. Epub 2024 Aug 30. Science. 2024. PMID: 39116259

7

What Is Our Current Understanding of PrP^Sc-Associated Neurotoxicity and Its Molecular Underpinnings?

Hughes D, Halliday M. Hughes D, et al. Pathogens. 2017 Dec 1;6(4):63. doi: 10.3390/pathogens6040063. Pathogens. 2017. PMID: 29194372 Free PMC article. Review.

8

Risk of bias tools for medication adherence research: RoBIAS and RoBOAS.

Sinnappah KA, Hughes DA, Stocker SL, Wright DFB; ESPACOMP the International Society for Medication Adherence. Sinnappah KA, et al. Among authors: hughes da. Br J Clin Pharmacol. 2025 Jan 21. doi: 10.1111/bcp.16382. Online ahead of print. Br J Clin Pharmacol. 2025. PMID: 39837562

9

External validation of the accuracy of cardiovascular risk prediction tools in psoriatic disease: a UK Biobank study.

Hughes DM, Yiu ZZN, Zhao SS. Hughes DM, et al. Clin Rheumatol. 2025 Jan 20. doi: 10.1007/s10067-025-07325-y. Online ahead of print. Clin Rheumatol. 2025. PMID: 39833655

10

Current and Emerging Therapies for Lysosomal Storage Disorders.

Lastoria DAA, Keynes S, Hughes D. Lastoria DAA, et al. Among authors: hughes d. Drugs. 2025 Jan 18. doi: 10.1007/s40265-025-02145-5. Online ahead of print. Drugs. 2025. PMID: 39826077 Review.

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