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Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R.
Sundqvist M, Christenson K, Holdfeldt A, Gabl M, Mårtensson J, Björkman L, Dieckmann R, Dahlgren C, Forsman H. Sundqvist M, et al. Among authors: holdfeldt a. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):695-708. doi: 10.1016/j.bbamcr.2018.02.008. Epub 2018 Feb 22. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29477577 Free article.
A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism.
Gabl M, Holdfeldt A, Winther M, Oprea T, Bylund J, Dahlgren C, Forsman H. Gabl M, et al. Among authors: holdfeldt a. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1228-37. doi: 10.1016/j.bbamcr.2016.03.014. Epub 2016 Mar 18. Biochim Biophys Acta. 2016. PMID: 26996596 Free article.
The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment.
Björkman L, Mårtensson J, Winther M, Gabl M, Holdfeldt A, Uhrbom M, Bylund J, Højgaard Hansen A, Pandey SK, Ulven T, Forsman H, Dahlgren C. Björkman L, et al. Among authors: holdfeldt a. Mol Cell Biol. 2016 Sep 26;36(20):2583-95. doi: 10.1128/MCB.00161-16. Print 2016 Oct 15. Mol Cell Biol. 2016. PMID: 27503855 Free PMC article.
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism.
Lind S, Holdfeldt A, Mårtensson J, Sundqvist M, Björkman L, Forsman H, Dahlgren C. Lind S, et al. Among authors: holdfeldt a. FASEB J. 2019 Jun;33(6):6887-6903. doi: 10.1096/fj.201802309R. Epub 2019 Feb 26. FASEB J. 2019. PMID: 30808243
The receptor crosstalk, by which allosterically modulated FFA2Rs communicate with P2Y(2)Rs and generate NADPH oxidase activating signals downstream of Galphaq, represent a novel mechanism by which GPCR activities can be regulated from inside the plasma membrane. Further, t …
The receptor crosstalk, by which allosterically modulated FFA2Rs communicate with P2Y(2)Rs and generate NADPH oxidase activating signals dow …
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils.
Lind S, Holdfeldt A, Mårtensson J, Sundqvist M, Kenakin TP, Björkman L, Forsman H, Dahlgren C. Lind S, et al. Among authors: holdfeldt a. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118689. doi: 10.1016/j.bbamcr.2020.118689. Epub 2020 Feb 21. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 32092308 Free article.
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.
Fredriksson J, Holdfeldt A, Mårtensson J, Björkman L, Møller TC, Müllers E, Dahlgren C, Sundqvist M, Forsman H. Fredriksson J, et al. Among authors: holdfeldt a. Biochim Biophys Acta Mol Cell Res. 2022 Jul;1869(7):119262. doi: 10.1016/j.bbamcr.2022.119262. Epub 2022 Mar 25. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35341806 Free article.
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