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When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.
Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S. Bradbury ARM, et al. MAbs. 2018 May/Jun;10(4):539-546. doi: 10.1080/19420862.2018.1445456. Epub 2018 Mar 29. MAbs. 2018. PMID: 29485921 Free PMC article.
Binders based on dimerised immunoglobulin VH domains.
Sepúlveda J, Jin H, Sblattero D, Bradbury A, Burrone OR. Sepúlveda J, et al. J Mol Biol. 2003 Oct 17;333(2):355-65. doi: 10.1016/j.jmb.2003.08.033. J Mol Biol. 2003. PMID: 14529622
147 results