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When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.
Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, Glanville J, Wolf P, Frenzel A, Wong J, Koh XY, Eng HY, Lane D, Lefranc MP, Clark M, Dübel S. Bradbury ARM, et al. Among authors: dubel s. MAbs. 2018 May/Jun;10(4):539-546. doi: 10.1080/19420862.2018.1445456. Epub 2018 Mar 29. MAbs. 2018. PMID: 29485921 Free PMC article.
High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation.
Pelat T, Hust M, Laffly E, Condemine F, Bottex C, Vidal D, Lefranc MP, Dübel S, Thullier P. Pelat T, et al. Among authors: dubel s. Antimicrob Agents Chemother. 2007 Aug;51(8):2758-64. doi: 10.1128/AAC.01528-06. Epub 2007 May 21. Antimicrob Agents Chemother. 2007. PMID: 17517846 Free PMC article.
Phage display derived therapeutic antibodies.
Thie H, Meyer T, Schirrmann T, Hust M, Dübel S. Thie H, et al. Among authors: dubel s. Curr Pharm Biotechnol. 2008 Dec;9(6):439-46. doi: 10.2174/138920108786786349. Curr Pharm Biotechnol. 2008. PMID: 19075684 Review.
Affinity maturation by phage display.
Thie H, Voedisch B, Dübel S, Hust M, Schirrmann T. Thie H, et al. Among authors: dubel s. Methods Mol Biol. 2009;525:309-22, xv. doi: 10.1007/978-1-59745-554-1_16. Methods Mol Biol. 2009. PMID: 19252854
Oligomeric forms of single chain immunoglobulin (scIgG).
Schirrmann T, Menzel C, Hust M, Prilop J, Jostock T, Dübel S. Schirrmann T, et al. Among authors: dubel s. MAbs. 2010 Jan-Feb;2(1):73-6. doi: 10.4161/mabs.2.1.10784. Epub 2010 Jan 26. MAbs. 2010. PMID: 20081378 Free PMC article.
A human scFv antibody generation pipeline for proteome research.
Hust M, Meyer T, Voedisch B, Rülker T, Thie H, El-Ghezal A, Kirsch MI, Schütte M, Helmsing S, Meier D, Schirrmann T, Dübel S. Hust M, et al. Among authors: dubel s. J Biotechnol. 2011 Apr 10;152(4):159-70. doi: 10.1016/j.jbiotec.2010.09.945. Epub 2010 Sep 29. J Biotechnol. 2011. PMID: 20883731
Targeting antibodies to the cytoplasm.
Marschall AL, Frenzel A, Schirrmann T, Schüngel M, Dübel S. Marschall AL, et al. Among authors: dubel s. MAbs. 2011 Jan-Feb;3(1):3-16. doi: 10.4161/mabs.3.1.14110. Epub 2011 Jan 1. MAbs. 2011. PMID: 21099369 Free PMC article. Review.
227 results