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Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.
Kadoh Y, Miyoshi H, Matsumura T, Tanaka Y, Hongu M, Kimura M, Takedomi K, Omori K, Kotera J, Sasaki T, Kobayashi T, Taniguchi H, Watanabe Y, Kojima K, Sakamoto T, Himiyama T, Kawanishi E. Kadoh Y, et al. Among authors: sakamoto t. Chem Pharm Bull (Tokyo). 2018;66(3):243-250. doi: 10.1248/cpb.c17-00783. Chem Pharm Bull (Tokyo). 2018. PMID: 29491258 Free article.
N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors.
Yamamoto Y, Kawanishi E, Koga Y, Sakamaki S, Sakamoto T, Ueta K, Matsushita Y, Kuriyama C, Tsuda-Tsukimoto M, Nomura S. Yamamoto Y, et al. Among authors: sakamoto t. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5641-5. doi: 10.1016/j.bmcl.2013.08.042. Epub 2013 Aug 17. Bioorg Med Chem Lett. 2013. PMID: 23999047
Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.
Sakamoto T, Koga Y, Hikota M, Matsuki K, Murakami M, Kikkawa K, Fujishige K, Kotera J, Omori K, Morimoto H, Yamada K. Sakamoto T, et al. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5175-80. doi: 10.1016/j.bmcl.2014.09.082. Epub 2014 Oct 2. Bioorg Med Chem Lett. 2014. PMID: 25442307
Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Granberg KL, et al. Among authors: sakamoto t. J Med Chem. 2024 Mar 28;67(6):4419-4441. doi: 10.1021/acs.jmedchem.3c02184. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502782
Robotic Laparoscopy and Endoscopy Cooperative Surgery for Primary Appendiceal Mucinous Carcinoma Masquerading as Bladder Cancer: A Case Report.
Mizuno R, Maekawa H, Hida K, Goto T, Teramoto Y, Kinoshita H, Sakamoto T, Okumura S, Kasahara K, Hoshino N, Nishigori T, Okamura R, Itatani Y, Hisamori S, Tsunoda S, Obama K. Mizuno R, et al. Among authors: sakamoto t. Asian J Endosc Surg. 2025 Jan-Dec;18(1):e70021. doi: 10.1111/ases.70021. Asian J Endosc Surg. 2025. PMID: 39822065
A negative relationship between first-pass pulmonary vein isolation and body mass index in ablation index-guided pulmonary vein isolation.
Okamatsu H, Okumura K, Onishi F, Yoshimura A, Negishi K, Tsurugi T, Tanaka Y, Fujita M, Nakao K, Sakamoto T, Koyama J, Tomita H. Okamatsu H, et al. Among authors: sakamoto t. Heart Rhythm O2. 2024 Oct 10;5(12):890-899. doi: 10.1016/j.hroo.2024.09.020. eCollection 2024 Dec. Heart Rhythm O2. 2024. PMID: 39803623 Free PMC article.
5,429 results