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A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.
Romano G, Chen PL, Song P, McQuade JL, Liang RJ, Liu M, Roh W, Duose DY, Carapeto FCL, Li J, Teh JLF, Aplin AE, Chen M, Zhang J, Lazar AJ, Davies MA, Futreal PA, Amaria RN, Zhang DY, Wargo JA, Kwong LN. Romano G, et al. Among authors: aplin ae. Cancer Discov. 2018 May;8(5):556-567. doi: 10.1158/2159-8290.CD-17-0745. Epub 2018 Mar 1. Cancer Discov. 2018. PMID: 29496665 Free PMC article.
Mechanisms of resistance to RAF inhibitors in melanoma.
Aplin AE, Kaplan FM, Shao Y. Aplin AE, et al. J Invest Dermatol. 2011 Sep;131(9):1817-20. doi: 10.1038/jid.2011.147. Epub 2011 May 19. J Invest Dermatol. 2011. PMID: 21593776 Free PMC article. Review.
Adaptive resistance to RAF inhibitors in melanoma.
Kugel CH 3rd, Aplin AE. Kugel CH 3rd, et al. Among authors: aplin ae. Pigment Cell Melanoma Res. 2014 Nov;27(6):1032-8. doi: 10.1111/pcmr.12264. Epub 2014 Jun 6. Pigment Cell Melanoma Res. 2014. PMID: 24828387 Free PMC article. Review.
167 results