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Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR. Prabakaran T, et al. Among authors: jensen sb. EMBO J. 2018 Apr 13;37(8):e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1. EMBO J. 2018. PMID: 29496741 Free PMC article.
Sensing the hybrid--a novel PAMP for TLR9.
Jensen SB, Paludan SR. Jensen SB, et al. EMBO J. 2014 Mar 18;33(6):529-30. doi: 10.1002/embj.201487747. Epub 2014 Feb 12. EMBO J. 2014. PMID: 24521669 Free PMC article.
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. Christensen MH, et al. Among authors: jensen sb. EMBO J. 2016 Jul 1;35(13):1385-99. doi: 10.15252/embj.201593458. Epub 2016 May 27. EMBO J. 2016. PMID: 27234299 Free PMC article.
STEEP mediates STING ER exit and activation of signaling.
Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR. Zhang BC, et al. Among authors: jensen sb. Nat Immunol. 2020 Aug;21(8):868-879. doi: 10.1038/s41590-020-0730-5. Epub 2020 Jul 20. Nat Immunol. 2020. PMID: 32690950 Free PMC article.
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.
Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR. Jønsson KL, et al. Among authors: jensen sb. Nat Commun. 2017 Feb 10;8:14391. doi: 10.1038/ncomms14391. Nat Commun. 2017. PMID: 28186168 Free PMC article.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Holm CK, et al. Among authors: jensen sb. Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350. Nat Immunol. 2012. PMID: 22706339 Free PMC article.
Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids.
Sun C, Luecke S, Bodda C, Jønsson KL, Cai Y, Zhang BC, Jensen SB, Nordentoft I, Jensen JM, Jakobsen MR, Paludan SR. Sun C, et al. Among authors: jensen jm, jensen sb. J Interferon Cytokine Res. 2019 Apr;39(4):191-204. doi: 10.1089/jir.2018.0141. Epub 2019 Mar 11. J Interferon Cytokine Res. 2019. PMID: 30855198
Author Correction: STEEP mediates STING ER exit and activation of signaling.
Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR. Zhang BC, et al. Among authors: jensen sb. Nat Immunol. 2020 Nov;21(11):1468-1469. doi: 10.1038/s41590-020-0803-5. Nat Immunol. 2020. PMID: 32929276
284 results