O'Connor CL - Search Results

1

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

Crawford N, Salvucci M, Hellwig CT, Lincoln FA, Mooney RE, O'Connor CL, Prehn JH, Longley DB, Rehm M. Crawford N, et al. Cell Death Differ. 2018 Nov;25(11):1952-1966. doi: 10.1038/s41418-018-0082-y. Epub 2018 Mar 2. Cell Death Differ. 2018. PMID: 29500433 Free PMC article.

2

Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein.

O'Connor CL, Anguissola S, Huber HJ, Dussmann H, Prehn JH, Rehm M. O'Connor CL, et al. Biochim Biophys Acta. 2008 Oct;1783(10):1903-13. doi: 10.1016/j.bbamcr.2008.05.025. Epub 2008 Jun 11. Biochim Biophys Acta. 2008. PMID: 18590777 Free article.

3

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

Schmid J, Dussmann H, Boukes GJ, Flanagan L, Lindner AU, O'Connor CL, Rehm M, Prehn JH, Huber HJ. Schmid J, et al. J Biol Chem. 2012 Nov 30;287(49):41546-59. doi: 10.1074/jbc.M112.411827. Epub 2012 Oct 4. J Biol Chem. 2012. PMID: 23038270 Free PMC article.

4

Saturation mutagenesis-reinforced functional assays for disease-related genes.

Ma K, Huang S, Ng KK, Lake NJ, Joseph S, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Cohen J, Ho V, O'Connor CL, Brindley MA, Campbell KP, Lek M. Ma K, et al. Among authors: o connor cl. Cell. 2024 Nov 14;187(23):6707-6724.e22. doi: 10.1016/j.cell.2024.08.047. Epub 2024 Sep 25. Cell. 2024. PMID: 39326416

5

Spatial Heterogeneity of Glomerular Phenotypes Affects Kidney Biopsy Findings.

Schaub JA, O'Connor CL, Dailey M, Hlynka AW, Chang Y, Postiff D, Kaffenberger SD, Palapattu GS, Gillespie BW, Hodgin JB, Shedden K, Bitzer M. Schaub JA, et al. Among authors: o connor cl. Kidney360. 2023 Nov 1;4(11):1598-1607. doi: 10.34067/KID.0000000000000283. Epub 2023 Oct 27. Kidney360. 2023. PMID: 37889598 Free PMC article.

6

Deep Mutational Scanning in Disease-related Genes with Saturation Mutagenesis-Reinforced Functional Assays (SMuRF).

Ma K, Huang S, Ng KK, Lake NJ, Joseph S, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Cohen J, Ho V, O'Connor CL, Brindley MA, Campbell KP, Lek M. Ma K, et al. Among authors: o connor cl. bioRxiv [Preprint]. 2024 Jun 25:2023.07.12.548370. doi: 10.1101/2023.07.12.548370. bioRxiv. 2024. Update in: Cell. 2024 Nov 14;187(23):6707-6724.e22. doi: 10.1016/j.cell.2024.08.047 PMID: 37873263 Free PMC article. Updated. Preprint.

7

SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes.

Schaub JA, AlAkwaa FM, McCown PJ, Naik AS, Nair V, Eddy S, Menon R, Otto EA, Demeke D, Hartman J, Fermin D, O'Connor CL, Subramanian L, Bitzer M, Harned R, Ladd P, Pyle L, Pennathur S, Inoki K, Hodgin JB, Brosius FC 3rd, Nelson RG, Kretzler M, Bjornstad P. Schaub JA, et al. Among authors: o connor cl. J Clin Invest. 2023 Mar 1;133(5):e164486. doi: 10.1172/JCI164486. J Clin Invest. 2023. PMID: 36637914 Free PMC article.

8

Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.

Atchison DK, O'Connor CL, Converso-Baran K, Bergin IL, Zhang H, Wang Y, Hartman JR, Ju W, Smrcka AV, Ganesh SK, Bitzer M. Atchison DK, et al. Among authors: o connor cl. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1376-H1387. doi: 10.1152/ajpheart.00262.2022. Epub 2022 Nov 11. Am J Physiol Heart Circ Physiol. 2022. PMID: 36367690 Free PMC article.

9

Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms.

Li H, Eksi R, Yi D, Godfrey B, Mathew LR, O'Connor CL, Bitzer M, Kretzler M, Menon R, Guan Y. Li H, et al. Among authors: o connor cl. PLoS Comput Biol. 2022 Apr 25;18(4):e1010040. doi: 10.1371/journal.pcbi.1010040. eCollection 2022 Apr. PLoS Comput Biol. 2022. PMID: 35468141 Free PMC article.

10

Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney.

Naik AS, Wang SQ, Chowdhury M, Aqeel J, O'Connor CL, Wiggins JE, Bitzer M, Wiggins RC. Naik AS, et al. Among authors: o connor cl. Sci Rep. 2021 Oct 1;11(1):19605. doi: 10.1038/s41598-021-99124-z. Sci Rep. 2021. PMID: 34599260 Free PMC article.

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