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The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.
Bokhovchuk FM, Bate N, Kovalevskaya NV, Goult BT, Spronk CAEM, Vuister GW. Bokhovchuk FM, et al. Among authors: bate n. Biochemistry. 2018 May 8;57(18):2623-2635. doi: 10.1021/acs.biochem.7b01287. Epub 2018 Apr 20. Biochemistry. 2018. PMID: 29584409 Free article.
We demonstrate that under these conditions the TRPV5 C-terminus is exclusively bound to the CaM C-lobe only, while it confers conformational freedom to the CaM N-lobe. We also show that at elevated calcium levels, additional interactions between the TRPV5 C-terminus and Ca …
We demonstrate that under these conditions the TRPV5 C-terminus is exclusively bound to the CaM C-lobe only, while it confers conformational …
The structure of an interdomain complex that regulates talin activity.
Goult BT, Bate N, Anthis NJ, Wegener KL, Gingras AR, Patel B, Barsukov IL, Campbell ID, Roberts GC, Critchley DR. Goult BT, et al. Among authors: bate n. J Biol Chem. 2009 May 29;284(22):15097-106. doi: 10.1074/jbc.M900078200. Epub 2009 Mar 18. J Biol Chem. 2009. PMID: 19297334 Free PMC article.
NMR assignment of the C-terminal actin-binding domain of talin.
Goult BT, Gingras AR, Bate N, Roberts GC, Critchley DR, Barsukov IL. Goult BT, et al. Among authors: bate n. Biomol NMR Assign. 2008 Jun;2(1):17-9. doi: 10.1007/s12104-007-9073-5. Epub 2007 Dec 22. Biomol NMR Assign. 2008. PMID: 19636914
Central region of talin has a unique fold that binds vinculin and actin.
Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR. Gingras AR, et al. Among authors: bate n. J Biol Chem. 2010 Sep 17;285(38):29577-87. doi: 10.1074/jbc.M109.095455. Epub 2010 Jul 7. J Biol Chem. 2010. PMID: 20610383 Free PMC article.
72 results