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Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition.
Hashimoto T, Kim GE, Tunin RS, Adesiyun T, Hsu S, Nakagawa R, Zhu G, O'Brien JJ, Hendrick JP, Davis RE, Yao W, Beard D, Hoxie HR, Wennogle LP, Lee DI, Kass DA. Hashimoto T, et al. Among authors: zhu g. Circulation. 2018 Oct 30;138(18):1974-1987. doi: 10.1161/CIRCULATIONAHA.117.030490. Circulation. 2018. PMID: 30030415 Free PMC article.
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA. Ranek MJ, et al. Among authors: zhu g. Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30. Nature. 2019. PMID: 30700906 Free PMC article.
The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
Chronic Atrial and Ventricular Pacing in the Mouse.
Ståhlberg M, Nakagawa R, Bedja D, Zhu G, Lin BL, Saberi A, Lee DI, Kass DA. Ståhlberg M, et al. Among authors: zhu g. Circ Heart Fail. 2019 Feb;12(2):e005655. doi: 10.1161/CIRCHEARTFAILURE.118.005655. Circ Heart Fail. 2019. PMID: 30764638 Free PMC article.
In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.
Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS. Lin BL, et al. Among authors: zhu g. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. doi: 10.1073/pnas.1815354116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028142 Free PMC article.
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA. Lee DI, et al. Among authors: zhu g. Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18. Nature. 2015. PMID: 25799991 Free PMC article.
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