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Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.
Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P, Shamir AM, Dai J, Puscheck EE, Secor E, Rappolee DA. Bolnick A, et al. Among authors: shamir am. J Assist Reprod Genet. 2017 Dec;34(12):1609-1617. doi: 10.1007/s10815-017-1028-x. Epub 2017 Sep 15. J Assist Reprod Genet. 2017. PMID: 28913567 Free PMC article.
Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos.
Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P, Shamir AM, Dai J, Puscheck EE, Rappolee DA. Bolnick A, et al. Among authors: shamir am. J Assist Reprod Genet. 2016 Aug;33(8):1027-39. doi: 10.1007/s10815-016-0735-z. Epub 2016 May 26. J Assist Reprod Genet. 2016. PMID: 27230877 Free PMC article.