van Maanen EMT - Search Results

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Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP.

van Maanen EMT, van Steeg TJ, Ahsman MJ, Michener MS, Savage MJ, Kennedy ME, Kleijn HJ, Stone J, Danhof M. van Maanen EMT, et al. J Pharmacol Exp Ther. 2018 Jun;365(3):507-518. doi: 10.1124/jpet.117.244699. Epub 2018 Mar 21. J Pharmacol Exp Ther. 2018. PMID: 29563326

Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool.

van Maanen EM, van Steeg TJ, Michener MS, Savage MJ, Kennedy ME, Kleijn HJ, Stone JA, Danhof M. van Maanen EM, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):205-16. doi: 10.1124/jpet.115.230565. Epub 2016 Jan 29. J Pharmacol Exp Ther. 2016. PMID: 26826190

Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases.

Bloomingdale P, Bakshi S, Maass C, van Maanen E, Pichardo-Almarza C, Yadav DB, van der Graaf P, Mehrotra N. Bloomingdale P, et al. J Pharmacokinet Pharmacodyn. 2021 Dec;48(6):861-871. doi: 10.1007/s10928-021-09776-7. Epub 2021 Aug 10. J Pharmacokinet Pharmacodyn. 2021. PMID: 34378151 Free PMC article.

Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression.

Datson NA, Polman JA, de Jonge RT, van Boheemen PT, van Maanen EM, Welten J, McEwen BS, Meiland HC, Meijer OC. Datson NA, et al. Endocrinology. 2011 Oct;152(10):3749-57. doi: 10.1210/en.2011-0287. Epub 2011 Aug 16. Endocrinology. 2011. PMID: 21846803

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