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IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.
Herjan T, Hong L, Bubenik J, Bulek K, Qian W, Liu C, Li X, Chen X, Yang H, Ouyang S, Zhou H, Zhao J, Vasu K, Cockman E, Aronica M, Asosingh K, Licatalosi DD, Qin J, Fox PL, Hamilton TA, Driscoll D, Li X. Herjan T, et al. Among authors: zhou h. Nat Immunol. 2018 Apr;19(4):354-365. doi: 10.1038/s41590-018-0071-9. Epub 2018 Mar 21. Nat Immunol. 2018. PMID: 29563620 Free PMC article.
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.
Zhou H, Bulek K, Li X, Herjan T, Yu M, Qian W, Wang H, Zhou G, Chen X, Yang H, Hong L, Zhao J, Qin L, Fukuda K, Flotho A, Gao J, Dongre A, Carman JA, Kang Z, Su B, Kern TS, Smith JD, Hamilton TA, Melchior F, Fox PL, Li X. Zhou H, et al. Among authors: zhou g. Elife. 2017 Oct 9;6:e29630. doi: 10.7554/eLife.29630. Elife. 2017. PMID: 28990926 Free PMC article.
IKKα negatively regulates ASC-dependent inflammasome activation.
Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. Martin BN, et al. Among authors: zhou h. Nat Commun. 2014 Sep 30;5:4977. doi: 10.1038/ncomms5977. Nat Commun. 2014. PMID: 25266676 Free PMC article.
Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.
Zhao J, Bulek K, Gulen MF, Zepp JA, Karagkounis G, Martin BN, Zhou H, Yu M, Liu X, Huang E, Fox PL, Kalady MF, Markowitz SD, Li X. Zhao J, et al. Among authors: zhou h. Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5. Gastroenterology. 2015. PMID: 26344057 Free PMC article.
TH17 cells promote CNS inflammation by sensing danger signals via Mincle.
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, Nagy LE, Li X. Zhang Q, et al. Among authors: zhou h. Nat Commun. 2022 May 3;13(1):2406. doi: 10.1038/s41467-022-30174-1. Nat Commun. 2022. PMID: 35504893 Free PMC article.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. Deng Z, et al. Among authors: zhou h. Nat Immunol. 2015 Jun;16(6):642-52. doi: 10.1038/ni.3155. Epub 2015 Apr 27. Nat Immunol. 2015. PMID: 25915733 Free PMC article.
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