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Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD.
Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R; Genetics of NAFLD in Twins Consortium. Caussy C, et al. Among authors: chen ch. Hepatology. 2018 Sep;68(3):918-932. doi: 10.1002/hep.29892. Epub 2018 May 20. Hepatology. 2018. PMID: 29572891 Free PMC article.
Modeling the 3D geometry of the cortical surface with genetic ancestry.
Fan CC, Bartsch H, Schork AJ, Chen CH, Wang Y, Lo MT, Brown TT, Kuperman JM, Hagler DJ Jr, Schork NJ, Jernigan TL, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study. Fan CC, et al. Among authors: chen ch. Curr Biol. 2015 Aug 3;25(15):1988-92. doi: 10.1016/j.cub.2015.06.006. Epub 2015 Jul 9. Curr Biol. 2015. PMID: 26166778 Free PMC article.
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM; Pediatric Imaging Neurocognition and Genetics Study; Alzheimer's Disease Neuroimaging Initiative. Chen CH, et al. Nat Commun. 2015 Jul 20;6:7549. doi: 10.1038/ncomms8549. Nat Commun. 2015. PMID: 26189703 Free PMC article.
Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study.
Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D; Genetics of NAFLD in Twins Consortium. Loomba R, et al. Among authors: chen ch. Gastroenterology. 2015 Dec;149(7):1784-93. doi: 10.1053/j.gastro.2015.08.011. Epub 2015 Aug 20. Gastroenterology. 2015. PMID: 26299412 Free PMC article.
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics.
Holland D, Wang Y, Thompson WK, Schork A, Chen CH, Lo MT, Witoelar A; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Enhancing Neuro Imaging Genetics through Meta Analysis Consortium; Werge T, O'Donovan M, Andreassen OA, Dale AM. Holland D, et al. Among authors: chen ch. Front Genet. 2016 Feb 16;7:15. doi: 10.3389/fgene.2016.00015. eCollection 2016. Front Genet. 2016. PMID: 26909100 Free PMC article.
Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study.
Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin CB, Loomba R, For The Genetics Of Nafld In Twins Consortium. Cui J, et al. Among authors: chen ch. Hepatology. 2016 Nov;64(5):1547-1558. doi: 10.1002/hep.28674. Epub 2016 Jul 25. Hepatology. 2016. PMID: 27315352 Free PMC article.
Conservation of Distinct Genetically-Mediated Human Cortical Pattern.
Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Dale AM, Schork NJ, Chen CH. Peng Q, et al. Among authors: chen ch. PLoS Genet. 2016 Jul 26;12(7):e1006143. doi: 10.1371/journal.pgen.1006143. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27459196 Free PMC article.
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.
Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. Loomba R, et al. Among authors: chen ch. Cell Metab. 2017 May 2;25(5):1054-1062.e5. doi: 10.1016/j.cmet.2017.04.001. Cell Metab. 2017. PMID: 28467925 Free PMC article.
Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis.
Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R; Familial NAFLD Cirrhosis Research Consortium. Caussy C, et al. Among authors: chen ch. J Clin Invest. 2017 Jun 30;127(7):2697-2704. doi: 10.1172/JCI93465. Epub 2017 Jun 19. J Clin Invest. 2017. PMID: 28628033 Free PMC article. Clinical Trial.
9,079 results