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Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.
Imanishi M, Tomishima Y, Itou S, Hamashima H, Nakajima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: imamura e. J Med Chem. 2008 Mar 27;51(6):1925-44. doi: 10.1021/jm701324c. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18307290
Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.
Imanishi M, Itou S, Washizuka K, Hamashima H, Nakajima Y, Araki T, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: imamura e. J Med Chem. 2008 Jul 10;51(13):4002-20. doi: 10.1021/jm8000345. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553954
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Hattori K, Toda S, Imanishi M, Itou S, Nakajima Y, Washizuka K, Araki T, Hamashima H, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F. Hattori K, et al. Among authors: imamura e. J Med Chem. 2009 May 14;52(9):3063-72. doi: 10.1021/jm9000709. J Med Chem. 2009. PMID: 19366244
Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction.
Inami H, Mizutani T, Watanabe J, Hayashida H, Ito T, Terasawa T, Kontani T, Yamagishi H, Usuda H, Aoyama N, Imamura E, Ishikawa T. Inami H, et al. Among authors: imamura e. Bioorg Med Chem. 2023 May 3;87:117302. doi: 10.1016/j.bmc.2023.117302. Epub 2023 May 3. Bioorg Med Chem. 2023. PMID: 37201454
Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.
Imanishi M, Nakajima Y, Tomishima Y, Hamashima H, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: imamura e. J Med Chem. 2008 Aug 14;51(15):4804-22. doi: 10.1021/jm800222k. Epub 2008 Jul 24. J Med Chem. 2008. PMID: 18651730
174 results