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Page 1
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.
McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG Jr. McBrayer SK, et al. Among authors: bronson rt. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3741-E3748. doi: 10.1073/pnas.1716029115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610306 Free PMC article.
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q. Lin W, et al. Among authors: bronson rt. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13379-86. doi: 10.1073/pnas.1110104108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788502 Free PMC article.
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG Jr. Oser MG, et al. Among authors: bronson rt. Genes Dev. 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119. Epub 2019 Nov 14. Genes Dev. 2019. PMID: 31727771 Free PMC article.
BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model.
He Y, Rivera J, Diossy M, Duan H, Bowman-Colin C, Reed R, Jennings R, Novak J, Tran SV, Cohen EF, Szuts D, Giobbie-Hurder A, Bronson RT, Bass AJ, Signoretti S, Szallasi Z, Livingston DM, Pathania S. He Y, et al. Among authors: bronson rt. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2108421118. doi: 10.1073/pnas.2108421118. Proc Natl Acad Sci U S A. 2021. PMID: 34607954 Free PMC article.
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.
Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG Jr, Livingston DM. Li AG, et al. Among authors: bronson rt. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9600-E9609. doi: 10.1073/pnas.1807112115. Epub 2018 Sep 25. Proc Natl Acad Sci U S A. 2018. PMID: 30254159 Free PMC article.
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG Jr. Lu G, et al. Among authors: bronson rt. Cancer Cell. 2014 Aug 11;26(2):222-34. doi: 10.1016/j.ccr.2014.06.026. Cancer Cell. 2014. PMID: 25117710 Free PMC article.
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG Jr, Bardeesy N, Wong KK. Akbay EA, et al. Among authors: bronson rt. Genes Dev. 2014 Mar 1;28(5):479-90. doi: 10.1101/gad.231233.113. Genes Dev. 2014. PMID: 24589777 Free PMC article.
548 results