Darwish KM - Search Results

1

Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-γ/FFAR1 agonists.

Darwish KM, Salama I, Mostafa S, Gomaa MS, Khafagy ES, Helal MA. Darwish KM, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1595-1602. doi: 10.1016/j.bmcl.2018.03.051. Epub 2018 Mar 21. Bioorg Med Chem Lett. 2018. PMID: 29615345

2

Extractional spectrophotometric analysis of metronidazole, tinidazole, ornidazole and secnidazole bases through acid-dye complexation using bromothymol blue dye.

Darwish KM, Salama I, Mostafa S, El-Sadek M. Darwish KM, et al. Pak J Pharm Sci. 2012 Jan;25(1):207-17. Pak J Pharm Sci. 2012. PMID: 22186332

3

RP-HPLC/pre-column derivatization for analysis of omeprazole, tinidazole, doxycycline and clarithromycin.

Darwish KM, Salama I, Mostafa S, El-Sadek M. Darwish KM, et al. J Chromatogr Sci. 2013 Jul;51(6):566-76. doi: 10.1093/chromsci/bms167. Epub 2012 Oct 18. J Chromatogr Sci. 2013. PMID: 23081968

4

Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin.

Darwish K, Salama I, Mostafa S, El-Sadek M. Darwish K, et al. Chem Pharm Bull (Tokyo). 2012;60(11):1426-36. doi: 10.1248/cpb.c12-00596. Chem Pharm Bull (Tokyo). 2012. PMID: 23124566 Free article.

5

Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.

Helal MA, Darwish KM, Hammad MA. Helal MA, et al. Among authors: darwish km. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5330-6. doi: 10.1016/j.bmcl.2014.07.043. Epub 2014 Aug 7. Bioorg Med Chem Lett. 2014. PMID: 25441945

6

Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists.

Darwish KM, Salama I, Mostafa S, Gomaa MS, Helal MA. Darwish KM, et al. Eur J Med Chem. 2016 Feb 15;109:157-72. doi: 10.1016/j.ejmech.2015.12.049. Epub 2015 Dec 31. Eur J Med Chem. 2016. PMID: 26774923

7

The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme.

Malebari AM, Ibrahim TS, Salem IM, Salama I, Khayyat AN, Mostafa SM, El-Sabbagh OI, Darwish KM. Malebari AM, et al. Among authors: darwish km. Pharmaceuticals (Basel). 2020 Sep 18;13(9):252. doi: 10.3390/ph13090252. Pharmaceuticals (Basel). 2020. PMID: 32961906 Free PMC article.

8

Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein.

Nagy MI, Darwish KM, Kishk SM, Tantawy MA, Nasr AM, Qushawy M, Swidan SA, Mostafa SM, Salama I. Nagy MI, et al. Among authors: darwish km. Pharmaceuticals (Basel). 2021 Feb 1;14(2):113. doi: 10.3390/ph14020113. Pharmaceuticals (Basel). 2021. PMID: 33535550 Free PMC article.

9

Deciphering the molecular basis of the kappa opioid receptor selectivity: A Molecular Dynamics study.

Saleh AH, Abdelwaly A, Darwish KM, Eissa AAHM, Chittiboyina A, Helal MA. Saleh AH, et al. Among authors: darwish km. J Mol Graph Model. 2021 Jul;106:107940. doi: 10.1016/j.jmgm.2021.107940. Epub 2021 May 10. J Mol Graph Model. 2021. PMID: 34015577

10

Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus.

Khayat MT, Abbas HA, Ibrahim TS, Khayyat AN, Alharbi M, Darwish KM, Elhady SS, Khafagy ES, Safo MK, Hegazy WAH. Khayat MT, et al. Among authors: darwish km. Biomedicines. 2022 May 18;10(5):1169. doi: 10.3390/biomedicines10051169. Biomedicines. 2022. PMID: 35625906 Free PMC article.

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