Bu Y - Search Results

1

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).

Smolinski MP, Bu Y, Clements J, Gelman IH, Hegab T, Cutler DL, Fang JWS, Fetterly G, Kwan R, Barnett A, Lau JYN, Hangauer DG. Smolinski MP, et al. Among authors: bu y. J Med Chem. 2018 Jun 14;61(11):4704-4719. doi: 10.1021/acs.jmedchem.8b00164. Epub 2018 Apr 17. J Med Chem. 2018. PMID: 29617135

2

KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.

Ciesielski MJ, Bu Y, Munich SA, Teegarden P, Smolinski MP, Clements JL, Lau JYN, Hangauer DG, Fenstermaker RA. Ciesielski MJ, et al. Among authors: bu y. J Neurooncol. 2018 Dec;140(3):519-527. doi: 10.1007/s11060-018-2992-4. Epub 2018 Sep 20. J Neurooncol. 2018. PMID: 30238350

3

Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.

Urgaonkar S, Nosol K, Said AM, Nasief NN, Bu Y, Locher KP, Lau JYN, Smolinski MP. Urgaonkar S, et al. Among authors: bu y. J Med Chem. 2022 Jan 13;65(1):191-216. doi: 10.1021/acs.jmedchem.1c01272. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928144

4

v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex.

Bu Y, Gelman IH. Bu Y, et al. J Biol Chem. 2007 Sep 14;282(37):26725-26739. doi: 10.1074/jbc.M702885200. Epub 2007 Jul 10. J Biol Chem. 2007. PMID: 17626016 Free article.

5

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.

Sachdev S, Bu Y, Gelman IH. Sachdev S, et al. Among authors: bu y. BMC Cancer. 2009 Jan 12;9:12. doi: 10.1186/1471-2407-9-12. BMC Cancer. 2009. PMID: 19138410 Free PMC article.

6

SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.

Su B, Bu Y, Engelberg D, Gelman IH. Su B, et al. Among authors: bu y. J Biol Chem. 2010 Feb 12;285(7):4578-86. doi: 10.1074/jbc.M109.073494. Epub 2009 Dec 15. J Biol Chem. 2010. PMID: 20018890 Free PMC article.

7

Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities.

Fallah-Tafti A, Foroumadi A, Tiwari R, Shirazi AN, Hangauer DG, Bu Y, Akbarzadeh T, Parang K, Shafiee A. Fallah-Tafti A, et al. Among authors: bu y. Eur J Med Chem. 2011 Oct;46(10):4853-8. doi: 10.1016/j.ejmech.2011.07.050. Epub 2011 Aug 4. Eur J Med Chem. 2011. PMID: 21852023 Free article.

8

Ion Current-Based Proteomic Profiling for Understanding the Inhibitory Effect of Tumor Necrosis Factor Alpha on Myogenic Differentiation.

Tu C, Bu Y, Vujcic M, Shen S, Li J, Qu M, Hangauer D, Clements JL, Qu J. Tu C, et al. Among authors: bu y. J Proteome Res. 2016 Sep 2;15(9):3147-57. doi: 10.1021/acs.jproteome.6b00321. Epub 2016 Aug 17. J Proteome Res. 2016. PMID: 27480135

9

SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition.

Su B, Zheng Q, Vaughan MM, Bu Y, Gelman IH. Su B, et al. Among authors: bu y. Cancer Res. 2006 Jun 1;66(11):5599-607. doi: 10.1158/0008-5472.CAN-05-4123. Cancer Res. 2006. PMID: 16740695

10

Role for transcription factor TFII-I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src.

Bu Y, Gao L, Gelman IH. Bu Y, et al. Int J Cancer. 2011 Apr 15;128(8):1836-42. doi: 10.1002/ijc.25524. Int J Cancer. 2011. PMID: 20568114 Free PMC article.

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