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126 results

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Page 1
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease.
Tobin JV, Zimmer DP, Shea C, Germano P, Bernier SG, Liu G, Long K, Miyashiro J, Ranganath S, Jacobson S, Tang K, Im GJ, Sheppeck J 2nd, Moore JD, Sykes K, Wakefield J, Sarno R, Banijamali AR, Profy AT, Milne GT, Currie MG, Masferrer JL. Tobin JV, et al. Among authors: masferrer jl. J Pharmacol Exp Ther. 2018 Jun;365(3):664-675. doi: 10.1124/jpet.117.247429. Epub 2018 Apr 11. J Pharmacol Exp Ther. 2018. PMID: 29643251
The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis.
Flores-Costa R, Alcaraz-Quiles J, Titos E, López-Vicario C, Casulleras M, Duran-Güell M, Rius B, Diaz A, Hall K, Shea C, Sarno R, Currie M, Masferrer JL, Clària J. Flores-Costa R, et al. Among authors: masferrer jl. Br J Pharmacol. 2018 Mar;175(6):953-967. doi: 10.1111/bph.14137. Epub 2018 Jan 31. Br J Pharmacol. 2018. PMID: 29281143 Free PMC article.
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.
Zimmer DP, Shea CM, Tobin JV, Tchernychev B, Germano P, Sykes K, Banijamali AR, Jacobson S, Bernier SG, Sarno R, Carvalho A, Chien YT, Graul R, Buys ES, Jones JE, Wakefield JD, Price GM, Chickering JG, Milne GT, Currie MG, Masferrer JL. Zimmer DP, et al. Among authors: masferrer jl. Front Pharmacol. 2020 Apr 8;11:419. doi: 10.3389/fphar.2020.00419. eCollection 2020. Front Pharmacol. 2020. PMID: 32322204 Free PMC article.
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.
Liu G, Shea CM, Jones JE, Price GM, Warren W, Lonie E, Yan S, Currie MG, Profy AT, Masferrer JL, Zimmer DP. Liu G, et al. Among authors: masferrer jl. Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F697-F711. doi: 10.1152/ajprenal.00003.2020. Epub 2020 Aug 31. Am J Physiol Renal Physiol. 2020. PMID: 32865013 Free article.
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Banijamali AR, Carvalho AE, Wakefield JD, Germano P, Barden TC, Tobin JV, Zimmer DP, Masferrer JL, Profy AT, Currie MG, Todd Milne G. Banijamali AR, et al. Among authors: masferrer jl. Pharmacol Res Perspect. 2020 Apr;8(2):e00579. doi: 10.1002/prp2.579. Pharmacol Res Perspect. 2020. PMID: 32314550 Free PMC article.
Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease.
Tchernychev B, Li H, Lee SK, Gao X, Ramanarasimhaiah R, Liu G, Hall KC, Bernier SG, Jones JE, Feil S, Feil R, Buys ES, Graul RM, Frenette PS, Masferrer JL. Tchernychev B, et al. Among authors: masferrer jl. Br J Pharmacol. 2021 Sep;178(17):3463-3475. doi: 10.1111/bph.15492. Epub 2021 May 30. Br J Pharmacol. 2021. PMID: 33864386 Free PMC article.
126 results