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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.
Phillips BW, Schlage WK, Titz B, Kogel U, Sciuscio D, Martin F, Leroy P, Vuillaume G, Krishnan S, Lee T, Veljkovic E, Elamin A, Merg C, Ivanov NV, Peitsch MC, Hoeng J, Vanscheeuwijck P. Phillips BW, et al. Among authors: merg c. Food Chem Toxicol. 2018 Jun;116(Pt B):388-413. doi: 10.1016/j.fct.2018.04.015. Epub 2018 Apr 11. Food Chem Toxicol. 2018. PMID: 29654848 Free article.
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.
Cabanski M, Fields B, Boue S, Boukharov N, DeLeon H, Dror N, Geertz M, Guedj E, Iskandar A, Kogel U, Merg C, Peck MJ, Poussin C, Schlage WK, Talikka M, Ivanov NV, Hoeng J, Peitsch MC. Cabanski M, et al. Among authors: merg c. Inflamm Res. 2015 Jul;64(7):471-86. doi: 10.1007/s00011-015-0820-2. Epub 2015 May 12. Inflamm Res. 2015. PMID: 25962837 Free PMC article.
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.
Ansari S, Baumer K, Boué S, Dijon S, Dulize R, Ekroos K, Elamin A, Foong C, Guedj E, Hoeng J, Ivanov NV, Krishnan S, Leroy P, Martin F, Merg C, Peck MJ, Peitsch MC, Phillips B, Schlage WK, Schneider T, Talikka M, Titz B, Vanscheeuwijck P, Veljkovic E, Vihervaara T, Vuillaume G, Woon CQ. Ansari S, et al. Among authors: merg c. Sci Data. 2016 Jan 5;3:150077. doi: 10.1038/sdata.2015.77. Sci Data. 2016. PMID: 26731301 Free PMC article.
Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.
Elamin A, Titz B, Dijon S, Merg C, Geertz M, Schneider T, Martin F, Schlage WK, Frentzel S, Talamo F, Phillips B, Veljkovic E, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J. Elamin A, et al. Among authors: merg c. J Proteomics. 2016 Aug 11;145:237-245. doi: 10.1016/j.jprot.2016.05.037. Epub 2016 Jun 5. J Proteomics. 2016. PMID: 27268958 Free article.
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.
Zanetti F, Sewer A, Mathis C, Iskandar AR, Kostadinova R, Schlage WK, Leroy P, Majeed S, Guedj E, Trivedi K, Martin F, Elamin A, Merg C, Ivanov NV, Frentzel S, Peitsch MC, Hoeng J. Zanetti F, et al. Among authors: merg c. Chem Res Toxicol. 2016 Aug 15;29(8):1252-69. doi: 10.1021/acs.chemrestox.6b00174. Epub 2016 Aug 5. Chem Res Toxicol. 2016. PMID: 27404394
A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.
Iskandar AR, Mathis C, Schlage WK, Frentzel S, Leroy P, Xiang Y, Sewer A, Majeed S, Ortega-Torres L, Johne S, Guedj E, Trivedi K, Kratzer G, Merg C, Elamin A, Martin F, Ivanov NV, Peitsch MC, Hoeng J. Iskandar AR, et al. Among authors: merg c. Toxicol In Vitro. 2017 Mar;39:29-51. doi: 10.1016/j.tiv.2016.11.009. Epub 2016 Nov 16. Toxicol In Vitro. 2017. PMID: 27865774 Free article.
The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product.
van der Toorn M, Sewer A, Marescotti D, Johne S, Baumer K, Bornand D, Dulize R, Merg C, Corciulo M, Scotti E, Pak C, Leroy P, Guedj E, Ivanov N, Martin F, Peitsch M, Hoeng J, Luettich K. van der Toorn M, et al. Among authors: merg c. Toxicol In Vitro. 2018 Aug;50:95-108. doi: 10.1016/j.tiv.2018.02.019. Epub 2018 Mar 7. Toxicol In Vitro. 2018. PMID: 29524472 Free article.
Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.
Iskandar AR, Martinez Y, Martin F, Schlage WK, Leroy P, Sewer A, Torres LO, Majeed S, Merg C, Trivedi K, Guedj E, Frentzel S, Mathis C, Ivanov NV, Peitsch MC, Hoeng J. Iskandar AR, et al. Among authors: merg c. Toxicol Res (Camb). 2017 Sep 28;6(6):930-946. doi: 10.1039/c7tx00152e. eCollection 2017 Nov 1. Toxicol Res (Camb). 2017. PMID: 30090554 Free PMC article.
22 results