Thiele DJ - Search Results

1

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE. Ran X, et al. Among authors: thiele dj. Bioorg Med Chem. 2018 Oct 15;26(19):5299-5306. doi: 10.1016/j.bmc.2018.04.018. Epub 2018 Apr 7. Bioorg Med Chem. 2018. PMID: 29661622 Free PMC article.

2

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Jaeger AM, et al. Among authors: thiele dj. J Biol Chem. 2014 Oct 31;289(44):30459-30469. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204655 Free PMC article.

3

Regulation of heat shock transcription factors and their roles in physiology and disease.

Gomez-Pastor R, Burchfiel ET, Thiele DJ. Gomez-Pastor R, et al. Among authors: thiele dj. Nat Rev Mol Cell Biol. 2018 Jan;19(1):4-19. doi: 10.1038/nrm.2017.73. Epub 2017 Aug 30. Nat Rev Mol Cell Biol. 2018. PMID: 28852220 Free PMC article. Review.

4

Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity.

Dong B, Jaeger AM, Thiele DJ. Dong B, et al. Among authors: thiele dj. Trends Pharmacol Sci. 2019 Dec;40(12):986-1005. doi: 10.1016/j.tips.2019.10.008. Epub 2019 Nov 11. Trends Pharmacol Sci. 2019. PMID: 31727393 Review.

5

Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation.

Burchfiel ET, Vihervaara A, Guertin MJ, Gomez-Pastor R, Thiele DJ. Burchfiel ET, et al. Among authors: thiele dj. J Biol Chem. 2021 Jan-Jun;296:100097. doi: 10.1074/jbc.RA120.015452. Epub 2020 Nov 24. J Biol Chem. 2021. PMID: 33208463 Free PMC article.

6

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.

Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Dong B, et al. Among authors: thiele dj. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. doi: 10.1126/scitranslmed.abb5647. Sci Transl Med. 2020. PMID: 33328331 Free PMC article.

7

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ. Gomez-Pastor R, et al. Among authors: thiele dj. Nat Commun. 2017 Feb 13;8:14405. doi: 10.1038/ncomms14405. Nat Commun. 2017. PMID: 28194040 Free PMC article.

8

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: thiele dj. Nat Rev Drug Discov. 2011 Dec 1;10(12):930-44. doi: 10.1038/nrd3453. Nat Rev Drug Discov. 2011. PMID: 22129991 Free PMC article. Review.

9

Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: thiele dj. G3 (Bethesda). 2013 Aug 7;3(8):1315-24. doi: 10.1534/g3.113.006692. G3 (Bethesda). 2013. PMID: 23733891 Free PMC article.

10

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.

Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ. Jaeger AM, et al. Among authors: thiele dj. Nat Struct Mol Biol. 2016 Feb;23(2):147-54. doi: 10.1038/nsmb.3150. Epub 2016 Jan 4. Nat Struct Mol Biol. 2016. PMID: 26727490 Free PMC article.

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