Jeggo R - Search Results

1

Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.

Andersen MA, Christensen KV, Badolo L, Smith GP, Jeggo R, Jensen PH, Andersen KJ, Sotty F. Andersen MA, et al. Among authors: jeggo r. Neurobiol Dis. 2018 Aug;116:13-27. doi: 10.1016/j.nbd.2018.04.011. Epub 2018 Apr 20. Neurobiol Dis. 2018. PMID: 29680709

2

PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats.

Andersen MA, Wegener KM, Larsen S, Badolo L, Smith GP, Jeggo R, Jensen PH, Sotty F, Christensen KV, Thougaard A. Andersen MA, et al. Among authors: jeggo r. Toxicology. 2018 Feb 15;395:15-22. doi: 10.1016/j.tox.2018.01.003. Epub 2018 Jan 4. Toxicology. 2018. PMID: 29307545 Free article.

3

Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications.

Andersen MA, Sotty F, Jensen PH, Badolo L, Jeggo R, Smith GP, Christensen KV. Andersen MA, et al. Among authors: jeggo r. eNeuro. 2019 Dec 19;6(6):ENEURO.0453-18.2019. doi: 10.1523/ENEURO.0453-18.2019. Print 2019 Nov/Dec. eNeuro. 2019. PMID: 31685675 Free PMC article.

4

Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?

Kristensen PJ, Heegaard AM, Hestehave S, Jeggo RD, Bjerrum OJ, Munro G. Kristensen PJ, et al. Among authors: jeggo rd. Eur J Pain. 2017 Apr;21(4):692-704. doi: 10.1002/ejp.973. Epub 2016 Nov 2. Eur J Pain. 2017. PMID: 27805755

5

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models.

O'Hare E, Scopes DI, Kim EM, Palmer P, Jones M, Whyment AD, Spanswick D, Amijee H, Nerou E, McMahon B, Treherne JM, Jeggo R. O'Hare E, et al. Among authors: jeggo r. Neurobiol Aging. 2013 Apr;34(4):1116-25. doi: 10.1016/j.neurobiolaging.2012.10.016. Epub 2012 Nov 17. Neurobiol Aging. 2013. PMID: 23164690

6

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.

Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.

7

Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease.

O'Hare E, Scopes DI, Kim EM, Palmer P, Spanswick D, McMahon B, Amijee H, Nerou E, Treherne JM, Jeggo R. O'Hare E, et al. Among authors: jeggo r. Int J Neuropsychopharmacol. 2014 Jan;17(1):117-26. doi: 10.1017/S1461145713000886. Epub 2013 Oct 8. Int J Neuropsychopharmacol. 2014. PMID: 24103729 Free article.

8

Lack of support for bexarotene as a treatment for Alzheimer's disease.

O'Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P, Lyons T, Page D, Hanna D, Meara JR, Spanswick D, Guo JP, McGeer EG, McGeer PL, Hobson P. O'Hare E, et al. Among authors: jeggo r. Neuropharmacology. 2016 Jan;100:124-30. doi: 10.1016/j.neuropharm.2015.04.020. Epub 2015 May 27. Neuropharmacology. 2016. PMID: 26025659 Free article.

9

Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity.

Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM. Scopes DI, et al. Among authors: jeggo r. Br J Pharmacol. 2012 Sep;167(2):383-92. doi: 10.1111/j.1476-5381.2012.01973.x. Br J Pharmacol. 2012. PMID: 22913627 Free PMC article.

10

MRZ-99030 - A novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice.

Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Spanswick D, O'Hare E, Palmer P, Kim EM, Bywalez W, Egger V, Parsons CG. Rammes G, et al. Among authors: jeggo r. Neuropharmacology. 2015 May;92:170-82. doi: 10.1016/j.neuropharm.2014.12.037. Epub 2015 Jan 28. Neuropharmacology. 2015. PMID: 25637092

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