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167 results

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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.
Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. Garrett M, et al. Among authors: pajonk f. Cancer Metab. 2018 Apr 17;6:4. doi: 10.1186/s40170-018-0177-4. eCollection 2018. Cancer Metab. 2018. PMID: 29692895 Free PMC article.
Metabolic state of glioma stem cells and nontumorigenic cells.
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Vlashi E, et al. Among authors: pajonk f. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16062-7. doi: 10.1073/pnas.1106704108. Epub 2011 Sep 7. Proc Natl Acad Sci U S A. 2011. PMID: 21900605 Free PMC article.
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Bhat K, et al. Among authors: pajonk f. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11085-11096. doi: 10.1073/pnas.1920154117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358191 Free PMC article.
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma.
He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. He L, et al. Among authors: pajonk f. Radiother Oncol. 2021 Aug;161:140-147. doi: 10.1016/j.radonc.2021.05.027. Epub 2021 Jun 5. Radiother Oncol. 2021. PMID: 34097975 Free PMC article.
P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.
Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. Muthukrishnan SD, et al. Among authors: pajonk f. Nat Commun. 2022 Oct 19;13(1):6202. doi: 10.1038/s41467-022-33943-0. Nat Commun. 2022. PMID: 36261421 Free PMC article.
Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1.
He L, Ioannidis A, Arambula E, Hoffman CJ, Joshi P, Kathiravan A, Whitelegge J, Liau LM, Kornblum HI, Pajonk F. He L, et al. Among authors: pajonk f. bioRxiv [Preprint]. 2023 Jul 25:2023.07.23.550205. doi: 10.1101/2023.07.23.550205. bioRxiv. 2023. Update in: Cancer Res Commun. 2024 Jun 25;4(6):1566-1580. doi: 10.1158/2767-9764.CRC-24-0049 PMID: 37546917 Free PMC article. Updated. Preprint.
167 results