Chou TC - Search Results

1

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.

Balog A, Harris C, Savin K, Zhang XG, Chou TC, Danishefsky SJ. Balog A, et al. Among authors: chou tc. Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2675-2678. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2675::AID-ANIE2675>3.0.CO;2-O. Angew Chem Int Ed Engl. 1998. PMID: 29711598

2

Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.

Chou TC, Dong H, Rivkin A, Yoshimura F, Gabarda AE, Cho YS, Tong WP, Danishefsky SJ. Chou TC, et al. Angew Chem Int Ed Engl. 2003 Oct 13;42(39):4762-7. doi: 10.1002/anie.200352361. Angew Chem Int Ed Engl. 2003. PMID: 14562342 No abstract available.

3

On the remarkable antitumor properties of fludelone: how we got there.

Rivkin A, Chou TC, Danishefsky SJ. Rivkin A, et al. Among authors: chou tc. Angew Chem Int Ed Engl. 2005 May 6;44(19):2838-50. doi: 10.1002/anie.200461751. Angew Chem Int Ed Engl. 2005. PMID: 15880547 Review.

4

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

Biswas K, Lin H, Njardarson JT, Chappell MD, Chou TC, Guan Y, Tong WP, He L, Horwitz SB, Danishefsky SJ. Biswas K, et al. Among authors: chou tc. J Am Chem Soc. 2002 Aug 21;124(33):9825-32. doi: 10.1021/ja0262333. J Am Chem Soc. 2002. PMID: 12175242

5

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

Chappell MD, Harris CR, Kuduk SD, Balog A, Wu Z, Zhang F, Lee CB, Stachel SJ, Danishefsky SJ, Chou TC, Guan Y. Chappell MD, et al. Among authors: chou tc. J Org Chem. 2002 Nov 1;67(22):7730-6. doi: 10.1021/jo020180q. J Org Chem. 2002. PMID: 12398496

6

Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.

Rivkin A, Njardarson JT, Biswas K, Chou TC, Danishefsky SJ. Rivkin A, et al. Among authors: chou tc. J Org Chem. 2002 Nov 1;67(22):7737-40. doi: 10.1021/jo0204294. J Org Chem. 2002. PMID: 12398497

7

On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings.

Rivkin A, Biswas K, Chou TC, Danishefsky SJ. Rivkin A, et al. Among authors: chou tc. Org Lett. 2002 Nov 14;4(23):4081-4. doi: 10.1021/ol0268283. Org Lett. 2002. PMID: 12423091

8

Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.

Yoshimura F, Rivkin A, Gabarda AE, Chou TC, Dong H, Sukenick G, Morel FF, Taylor RE, Danishefsky SJ. Yoshimura F, et al. Among authors: chou tc. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2518-21. doi: 10.1002/anie.200351407. Angew Chem Int Ed Engl. 2003. PMID: 12800175 No abstract available.

9

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

Chou TC, Zhang XG, Balog A, Su DS, Meng D, Savin K, Bertino JR, Danishefsky SJ. Chou TC, et al. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9642-7. doi: 10.1073/pnas.95.16.9642. Proc Natl Acad Sci U S A. 1998. PMID: 9689134 Free PMC article.

10

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

Chou TC, Zhang XG, Harris CR, Kuduk SD, Balog A, Savin KA, Bertino JR, Danishefsky SJ. Chou TC, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15798-802. doi: 10.1073/pnas.95.26.15798. Proc Natl Acad Sci U S A. 1998. PMID: 9861050 Free PMC article.

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