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Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens.
Trapp S, Soubieux D, Marty H, Esnault E, Hoffmann TW, Chandenier M, Lion A, Kut E, Quéré P, Larcher T, Ledevin M, Munier S, Naffakh N, Marc D. Trapp S, et al. Among authors: kut e. J Gen Virol. 2014 Jun;95(Pt 6):1233-1243. doi: 10.1099/vir.0.063776-0. Epub 2014 Apr 2. J Gen Virol. 2014. PMID: 24694396
Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape.
Lion A, Richard M, Esnault E, Kut E, Soubieux D, Guillory V, Germond M, Blondeau C, Guabiraba R, Short KR, Marc D, Quéré P, Trapp S. Lion A, et al. Among authors: kut e. Virology. 2018 Jan 1;513:29-42. doi: 10.1016/j.virol.2017.10.007. Epub 2017 Oct 12. Virology. 2018. PMID: 29031164 Free article.
Chicken endothelial cells are highly responsive to viral innate immune stimuli and are susceptible to infections with various avian pathogens.
Lion A, Esnault E, Kut E, Guillory V, Trapp-Fragnet L, Soubies SM, Chanteloup N, Niepceron A, Guabiraba R, Marc D, Eterradossi N, Trapp S, Quéré P. Lion A, et al. Among authors: kut e. Avian Pathol. 2019 Apr;48(2):121-134. doi: 10.1080/03079457.2018.1556386. Epub 2019 Jan 10. Avian Pathol. 2019. PMID: 30556415 Free article.
53 results