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Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Davis RJ, et al. Among authors: paddison pj. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735700 Free PMC article.
Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.
Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ. Toledo CM, et al. Among authors: paddison pj. Cell Rep. 2015 Dec 22;13(11):2425-2439. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7. Cell Rep. 2015. PMID: 26673326 Free PMC article.
Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.
Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Sripathy S, et al. Among authors: paddison pj. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1619-1624. doi: 10.1073/pnas.1621356114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143937 Free PMC article.
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Pattwell SS, Arora S, Cimino PJ, Ozawa T, Szulzewsky F, Hoellerbauer P, Bonifert T, Hoffstrom BG, Boiani NE, Bolouri H, Correnti CE, Oldrini B, Silber JR, Squatrito M, Paddison PJ, Holland EC. Pattwell SS, et al. Among authors: paddison pj. Nat Commun. 2020 Jun 12;11(1):2977. doi: 10.1038/s41467-020-16786-5. Nat Commun. 2020. PMID: 32532995 Free PMC article.
Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation.
Margres MJ, Ruiz-Aravena M, Hamede R, Chawla K, Patton AH, Lawrance MF, Fraik AK, Stahlke AR, Davis BW, Ostrander EA, Jones ME, McCallum H, Paddison PJ, Hohenlohe PA, Hockenbery D, Storfer A. Margres MJ, et al. Among authors: paddison pj. Genetics. 2020 Aug;215(4):1143-1152. doi: 10.1534/genetics.120.303428. Epub 2020 Jun 18. Genetics. 2020. PMID: 32554701 Free PMC article.
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis.
Szulzewsky F, Arora S, Hoellerbauer P, King C, Nathan E, Chan M, Cimino PJ, Ozawa T, Kawauchi D, Pajtler KW, Gilbertson RJ, Paddison PJ, Vasioukhin V, Gujral TS, Holland EC. Szulzewsky F, et al. Among authors: paddison pj. Genes Dev. 2020 Aug 1;34(15-16):1051-1064. doi: 10.1101/gad.338681.120. Epub 2020 Jul 16. Genes Dev. 2020. PMID: 32675324 Free PMC article.
Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.
O'Connor SA, Feldman HM, Arora S, Hoellerbauer P, Toledo CM, Corrin P, Carter L, Kufeld M, Bolouri H, Basom R, Delrow J, McFaline-Figueroa JL, Trapnell C, Pollard SM, Patel A, Paddison PJ, Plaisier CL. O'Connor SA, et al. Among authors: paddison pj. Mol Syst Biol. 2021 Jun;17(6):e9522. doi: 10.15252/msb.20209522. Mol Syst Biol. 2021. PMID: 34101353 Free PMC article.
63 results