Mandal P - Search Results

1

Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease.

Knight JM, Mandal P, Morlacchi P, Mak G, Li E, Madison M, Landers C, Saxton B, Felix E, Gilbert B, Sederstrom J, Varadhachary A, Singh MM, Chatterjee D, Corry DB, McMurray JS. Knight JM, et al. Among authors: mandal p. J Biol Chem. 2018 Jun 29;293(26):10026-10040. doi: 10.1074/jbc.RA117.000567. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739850 Free PMC article.

2

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6.

Morlacchi P, Mandal PK, McMurray JS. Morlacchi P, et al. Among authors: mandal pk. ACS Med Chem Lett. 2013 Dec 4;5(1):69-72. doi: 10.1021/ml4003919. eCollection 2014 Jan 9. ACS Med Chem Lett. 2013. PMID: 24900775 Free PMC article.

3

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.

Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR 4th, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Mandal PK, et al. J Med Chem. 2015 Nov 25;58(22):8970-84. doi: 10.1021/acs.jmedchem.5b01321. Epub 2015 Nov 9. J Med Chem. 2015. PMID: 26506089 Free PMC article.

4

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.

Coleman DR 4th, Ren Z, Mandal PK, Cameron AG, Dyer GA, Muranjan S, Campbell M, Chen X, McMurray JS. Coleman DR 4th, et al. J Med Chem. 2005 Oct 20;48(21):6661-70. doi: 10.1021/jm050513m. J Med Chem. 2005. PMID: 16220982

5

Pd-C-induced catalytic transfer hydrogenation with triethylsilane.

Mandal PK, McMurray JS. Mandal PK, et al. J Org Chem. 2007 Aug 17;72(17):6599-601. doi: 10.1021/jo0706123. Epub 2007 Jul 14. J Org Chem. 2007. PMID: 17630799

6

Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain.

McMurray JS, Mandal PK, Liao WS, Ren Z, Chen X. McMurray JS, et al. Adv Exp Med Biol. 2009;611:545-6. doi: 10.1007/978-0-387-73657-0_239. Adv Exp Med Biol. 2009. PMID: 19400306 No abstract available.

7

Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3.

Mandal PK, Liao WS, McMurray JS. Mandal PK, et al. Org Lett. 2009 Aug 6;11(15):3394-7. doi: 10.1021/ol9012662. Org Lett. 2009. PMID: 19594124 Free PMC article.

8

Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

Mandal PK, Ren Z, Chen X, Xiong C, McMurray JS. Mandal PK, et al. J Med Chem. 2009 Oct 8;52(19):6126-41. doi: 10.1021/jm901105k. J Med Chem. 2009. PMID: 19728728 Free PMC article.

9

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC Jr, Liao WS, McMurray JS. Mandal PK, et al. J Med Chem. 2011 May 26;54(10):3549-63. doi: 10.1021/jm2000882. Epub 2011 Apr 26. J Med Chem. 2011. PMID: 21486047 Free PMC article.

10

The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain.

McMurray JS, Mandal PK, Liao WS, Klostergaard J, Robertson FM. McMurray JS, et al. JAKSTAT. 2012 Oct 1;1(4):263-347. doi: 10.4161/jkst.22682. JAKSTAT. 2012. PMID: 24058783 Free PMC article. Review.

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