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Page 1
hIAPP forms toxic oligomers in plasma.
Rodriguez Camargo DC , Garg D , Buday K , Franko A , Rodriguez Camargo A , Schmidt F , Cox SJ , Suladze S , Haslbeck M , Mideksa YG , Gemmecker G , Aichler M , Mettenleiter G , Schulz M , Walch AK , Hrabě de Angelis M , Feige MJ , Sierra CA , Conrad M , Tripsianes K , Ramamoorthy A , Reif B . Rodriguez Camargo DC , et al. Among authors: aichler m. Chem Commun (Camb). 2018 May 24;54(43):5426-5429. doi: 10.1039/c8cc03097a. Chem Commun (Camb). 2018. PMID: 29745410 Free PMC article.
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B. Rodriguez Camargo DC, et al. Among authors: aichler m. Sci Rep. 2017 Mar 13;7:44041. doi: 10.1038/srep44041. Sci Rep. 2017. PMID: 28287098 Free PMC article.
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, Hrabě de Angelis M. Franko A, et al. Among authors: aichler m. Sci Rep. 2018 Jan 18;8(1):1116. doi: 10.1038/s41598-017-18807-8. Sci Rep. 2018. PMID: 29348618 Free PMC article.
Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, Brachthäuser L, Neff F, Kovarova M, Wolf E, Fuchs H, Häring HU, Peter A, Hrabě de Angelis M. Franko A, et al. Among authors: aichler m. Mol Metab. 2017 Jan 6;6(3):256-266. doi: 10.1016/j.molmet.2016.12.007. eCollection 2017 Mar. Mol Metab. 2017. PMID: 28271032 Free PMC article.
N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.
Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A. Aichler M, et al. Cell Metab. 2017 Jun 6;25(6):1334-1347.e4. doi: 10.1016/j.cmet.2017.04.012. Cell Metab. 2017. PMID: 28591636 Free article.
109 results