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The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever.
Seregin AV, Yun NE, Miller M, Aronson J, Smith JK, Walker AG, Smith JN, Huang C, Manning JT, de la Torre JC, Paessler S. Seregin AV, et al. Among authors: manning jt. J Virol. 2015 Jun;89(11):5949-56. doi: 10.1128/JVI.00104-15. Epub 2015 Mar 25. J Virol. 2015. PMID: 25810546 Free PMC article.
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression.
Manning JT, Seregin AV, Yun NE, Koma T, Huang C, Barral J, de la Torre JC, Paessler S. Manning JT, et al. Front Cell Infect Microbiol. 2017 Feb 6;7:20. doi: 10.3389/fcimb.2017.00020. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28220142 Free PMC article.
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.
Hallam SJ, Manning JT, Maruyama J, Seregin A, Huang C, Walker DH, de la Torre JC, Paessler S. Hallam SJ, et al. Among authors: manning jt. PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008555. doi: 10.1371/journal.pntd.0008555. eCollection 2020 Sep. PLoS Negl Trop Dis. 2020. PMID: 32976538 Free PMC article.
Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.
Koma T, Huang C, Coscia A, Hallam S, Manning JT, Maruyama J, Walker AG, Miller M, Smith JN, Patterson M, Abraham J, Paessler S. Koma T, et al. Among authors: manning jt. PLoS Pathog. 2021 Mar 1;17(3):e1009356. doi: 10.1371/journal.ppat.1009356. eCollection 2021 Mar. PLoS Pathog. 2021. PMID: 33647064 Free PMC article.
231 results