Leonhard WN - Search Results

1

Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.

Verschuren EHJ, Mohammed SG, Leonhard WN, Overmars-Bos C, Veraar K, Hoenderop JGJ, Bindels RJM, Peters DJM, Arjona FJ. Verschuren EHJ, et al. Among authors: leonhard wn. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F537-F546. doi: 10.1152/ajprenal.00622.2017. Epub 2018 May 16. Am J Physiol Renal Physiol. 2018. PMID: 29767557 Free article.

2

Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells.

Scheffers MS, Le H, van der Bent P, Leonhard W, Prins F, Spruit L, Breuning MH, de Heer E, Peters DJ. Scheffers MS, et al. Hum Mol Genet. 2002 Jan 1;11(1):59-67. doi: 10.1093/hmg/11.1.59. Hum Mol Genet. 2002. PMID: 11772999

3

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease.

Lantinga-van Leeuwen IS, Dauwerse JG, Baelde HJ, Leonhard WN, van de Wal A, Ward CJ, Verbeek S, Deruiter MC, Breuning MH, de Heer E, Peters DJ. Lantinga-van Leeuwen IS, et al. Among authors: leonhard wn. Hum Mol Genet. 2004 Dec 15;13(24):3069-77. doi: 10.1093/hmg/ddh336. Epub 2004 Oct 20. Hum Mol Genet. 2004. PMID: 15496422

4

Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions.

Lantinga-van Leeuwen IS, Leonhard WN, Dauwerse H, Baelde HJ, van Oost BA, Breuning MH, Peters DJ. Lantinga-van Leeuwen IS, et al. Among authors: leonhard wn. Eur J Hum Genet. 2005 May;13(5):649-59. doi: 10.1038/sj.ejhg.5201392. Eur J Hum Genet. 2005. PMID: 15770226

5

Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells.

Lantinga-van Leeuwen IS, Leonhard WN, van de Wal A, Breuning MH, Verbeek S, de Heer E, Peters DJ. Lantinga-van Leeuwen IS, et al. Among authors: leonhard wn. Genesis. 2006 May;44(5):225-32. doi: 10.1002/dvg.20207. Genesis. 2006. PMID: 16652363

6

Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.

Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A, Breuning MH, de Heer E, Peters DJ. Lantinga-van Leeuwen IS, et al. Among authors: leonhard wn. Hum Mol Genet. 2007 Dec 15;16(24):3188-96. doi: 10.1093/hmg/ddm299. Epub 2007 Oct 11. Hum Mol Genet. 2007. PMID: 17932118

7

Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice.

Leonhard WN, Roelfsema JH, Lantinga-van Leeuwen IS, Breuning MH, Peters DJ. Leonhard WN, et al. BMC Biotechnol. 2008 Feb 25;8:18. doi: 10.1186/1472-6750-8-18. BMC Biotechnol. 2008. PMID: 18298805 Free PMC article.

8

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways.

Happé H, Leonhard WN, van der Wal A, van de Water B, Lantinga-van Leeuwen IS, Breuning MH, de Heer E, Peters DJ. Happé H, et al. Among authors: leonhard wn. Hum Mol Genet. 2009 Jul 15;18(14):2532-42. doi: 10.1093/hmg/ddp190. Epub 2009 Apr 28. Hum Mol Genet. 2009. PMID: 19401297

9

Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.

Hassane S, Leonhard WN, van der Wal A, Hawinkels LJ, Lantinga-van Leeuwen IS, ten Dijke P, Breuning MH, de Heer E, Peters DJ. Hassane S, et al. Among authors: leonhard wn. J Pathol. 2010 Sep;222(1):21-31. doi: 10.1002/path.2734. J Pathol. 2010. PMID: 20549648

10

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

Leonhard WN, van der Wal A, Novalic Z, Kunnen SJ, Gansevoort RT, Breuning MH, de Heer E, Peters DJ. Leonhard WN, et al. Am J Physiol Renal Physiol. 2011 May;300(5):F1193-202. doi: 10.1152/ajprenal.00419.2010. Epub 2011 Feb 23. Am J Physiol Renal Physiol. 2011. PMID: 21345977 Free article.

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