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Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.
Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators. Sprigg N, et al. Among authors: law zk. Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16. Lancet. 2018. PMID: 29778325 Free PMC article. Clinical Trial.
Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.
Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, Seiffge D, Beredzie M; TICH-2 Investigators. Sprigg N, et al. Among authors: law zk. Int J Stroke. 2016 Aug;11(6):683-94. doi: 10.1177/1747493016641960. Epub 2016 Apr 5. Int J Stroke. 2016. PMID: 27048694 Clinical Trial.
Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.
Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM. Blair GW, et al. Among authors: law zk. Int J Stroke. 2018 Jul;13(5):530-538. doi: 10.1177/1747493017731947. Epub 2017 Sep 14. Int J Stroke. 2018. PMID: 28906205 Clinical Trial.
Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial.
Dineen RA, Pszczolkowski S, Flaherty K, Law ZK, Morgan PS, Roberts I, Werring DJ, Al-Shahi Salman R, England T, Bath PM, Sprigg N. Dineen RA, et al. Among authors: law zk. BMJ Open. 2018 Feb 3;8(2):e019930. doi: 10.1136/bmjopen-2017-019930. BMJ Open. 2018. PMID: 29431141 Free PMC article. Clinical Trial.
Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial.
Ovesen C, Jakobsen JC, Gluud C, Steiner T, Law Z, Flaherty K, Dineen RA, Bath PM, Sprigg N, Christensen H. Ovesen C, et al. BMC Res Notes. 2018 Jun 13;11(1):379. doi: 10.1186/s13104-018-3481-8. BMC Res Notes. 2018. PMID: 29895329 Free PMC article. Clinical Trial.
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