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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. White PJ, et al. Among authors: grimsrud pa. Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17. Cell Metab. 2018. PMID: 29779826 Free PMC article.
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD. Anderson KA, et al. Among authors: grimsrud pa. Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003. Cell Metab. 2017. PMID: 28380376 Free PMC article.
Statin therapy inhibits fatty acid synthase via dynamic protein modifications.
Trub AG, Wagner GR, Anderson KA, Crown SB, Zhang GF, Thompson JW, Ilkayeva OR, Stevens RD, Grimsrud PA, Kulkarni RA, Backos DS, Meier JL, Hirschey MD. Trub AG, et al. Among authors: grimsrud pa. Nat Commun. 2022 May 10;13(1):2542. doi: 10.1038/s41467-022-30060-w. Nat Commun. 2022. PMID: 35538051 Free PMC article.
Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Bhatt DP, Mills CA, Anderson KA, Henriques BJ, Lucas TG, Francisco S, Liu J, Ilkayeva OR, Adams AE, Kulkarni SR, Backos DS, Major MB, Grimsrud PA, Gomes CM, Hirschey MD. Bhatt DP, et al. Among authors: grimsrud pa. J Biol Chem. 2022 Apr;298(4):101723. doi: 10.1016/j.jbc.2022.101723. Epub 2022 Feb 12. J Biol Chem. 2022. PMID: 35157847 Free PMC article.
Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM. Fisher-Wellman KH, et al. Among authors: grimsrud pa. Cell Rep. 2019 Feb 5;26(6):1557-1572.e8. doi: 10.1016/j.celrep.2019.01.057. Cell Rep. 2019. PMID: 30726738 Free PMC article.
38 results