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Page 1
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Pleines I, et al. Among authors: henley kj. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21. Blood. 2018. PMID: 29784641 Free article.
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.
Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Schoenwaelder SM, et al. Among authors: henley kj. Blood. 2009 Jul 16;114(3):663-6. doi: 10.1182/blood-2009-01-200345. Epub 2009 Apr 22. Blood. 2009. PMID: 19387006 Free article.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. Among authors: henley kj. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Debrincat MA, et al. Among authors: henley kj. Blood. 2012 Jun 14;119(24):5850-8. doi: 10.1182/blood-2011-12-398834. Epub 2012 Feb 28. Blood. 2012. PMID: 22374700 Free article.
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease.
Mason KD, Lin A, Robb L, Josefsson EC, Henley KJ, Gray DH, Kile BT, Roberts AW, Strasser A, Huang DC, Waring P, O'Reilly LA. Mason KD, et al. Among authors: henley kj. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2599-604. doi: 10.1073/pnas.1215097110. Epub 2013 Jan 24. Proc Natl Acad Sci U S A. 2013. PMID: 23349374 Free PMC article.
18 results