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The yeast Sup35NM domain propagates as a prion in mammalian cells.
Krammer C, Kryndushkin D, Suhre MH, Kremmer E, Hofmann A, Pfeifer A, Scheibel T, Wickner RB, Schätzl HM, Vorberg I. Krammer C, et al. Among authors: vorberg i. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):462-7. doi: 10.1073/pnas.0811571106. Epub 2008 Dec 29. Proc Natl Acad Sci U S A. 2009. PMID: 19114662 Free PMC article.
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion.
Hafner-Bratkovic I, Bester R, Pristovsek P, Gaedtke L, Veranic P, Gaspersic J, Mancek-Keber M, Avbelj M, Polymenidou M, Julius C, Aguzzi A, Vorberg I, Jerala R. Hafner-Bratkovic I, et al. Among authors: vorberg i. J Biol Chem. 2011 Apr 8;286(14):12149-56. doi: 10.1074/jbc.M110.213926. Epub 2011 Feb 15. J Biol Chem. 2011. PMID: 21324909 Free PMC article.
Cellular aspects of prion replication in vitro.
Grassmann A, Wolf H, Hofmann J, Graham J, Vorberg I. Grassmann A, et al. Among authors: vorberg i. Viruses. 2013 Jan 22;5(1):374-405. doi: 10.3390/v5010374. Viruses. 2013. PMID: 23340381 Free PMC article. Review.
Cell-to-cell propagation of infectious cytosolic protein aggregates.
Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM. Hofmann JP, et al. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5951-6. doi: 10.1073/pnas.1217321110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509289 Free PMC article.
65 results