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Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.
Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W. Bayer T, et al. Among authors: marek m. ChemMedChem. 2018 Aug 10;13(15):1517-1529. doi: 10.1002/cmdc.201800238. Epub 2018 Jul 4. ChemMedChem. 2018. PMID: 29806110
Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C. Marek M, et al. PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26. PLoS Pathog. 2013. PMID: 24086136 Free PMC article.
ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A. Obri A, et al. Among authors: marek m. Nature. 2014 Jan 30;505(7485):648-53. doi: 10.1038/nature12922. Epub 2014 Jan 22. Nature. 2014. PMID: 24463511
Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Stolfa DA, et al. Among authors: marek m. J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20. J Mol Biol. 2014. PMID: 24657767 Free article.
Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.
Kulandaivelu U, Chilakamari LM, Jadav SS, Rao TR, Jayaveera KN, Shireesha B, Hauser AT, Senger J, Marek M, Romier C, Jung M, Jayaprakash V. Kulandaivelu U, et al. Among authors: marek m. Bioorg Chem. 2014 Dec;57:116-120. doi: 10.1016/j.bioorg.2014.08.005. Epub 2014 Sep 3. Bioorg Chem. 2014. PMID: 25462986
Schistosome sirtuins as drug targets.
Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ. Lancelot J, et al. Among authors: marek m. Future Med Chem. 2015;7(6):765-82. doi: 10.4155/fmc.15.24. Future Med Chem. 2015. PMID: 25996069 Review.
262 results