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Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Peters TL, Tillotson J, Yeomans AM, Wilmore S, Lemm E, Jiménez-Romero C, Amador LA, Li L, Amin AD, Pongtornpipat P, Zerio CJ, Ambrose AJ, Paine-Murrieta G, Greninger P, Vega F, Benes CH, Packham G, Rodríguez AD, Chapman E, Schatz JH. Peters TL, et al. Among authors: chapman e. Clin Cancer Res. 2018 Sep 1;24(17):4256-4270. doi: 10.1158/1078-0432.CCR-17-3645. Epub 2018 May 29. Clin Cancer Res. 2018. PMID: 29844128 Free PMC article.
Withaferin A Analogs That Target the AAA+ Chaperone p97.
Tao S, Tillotson J, Wijeratne EMK, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, Clair JJ, Gunatilaka AAL, Zhang DD, Chapman E. Tao S, et al. Among authors: chapman e. ACS Chem Biol. 2015 Aug 21;10(8):1916-1924. doi: 10.1021/acschembio.5b00367. Epub 2015 Jun 3. ACS Chem Biol. 2015. PMID: 26006219 Free PMC article.
Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii.
Wijeratne EM, Gunaherath GM, Chapla VM, Tillotson J, de la Cruz F, Kang M, U'Ren JM, Araujo AR, Arnold AE, Chapman E, Gunatilaka AA. Wijeratne EM, et al. Among authors: chapman e. J Nat Prod. 2016 Feb 26;79(2):340-52. doi: 10.1021/acs.jnatprod.5b00986. Epub 2016 Jan 26. J Nat Prod. 2016. PMID: 26812276 Free PMC article.
GroEL/ES inhibitors as potential antibiotics.
Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. Abdeen S, et al. Among authors: chapman e. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3127-3134. doi: 10.1016/j.bmcl.2016.04.089. Epub 2016 May 4. Bioorg Med Chem Lett. 2016. PMID: 27184767 Free article.
Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin.
Tillotson J, Bashyal BP, Kang M, Shi T, De La Cruz F, Gunatilaka AA, Chapman E. Tillotson J, et al. Among authors: chapman e. Org Biomol Chem. 2016 Jul 7;14(25):5918-21. doi: 10.1039/c6ob00560h. Epub 2016 May 25. Org Biomol Chem. 2016. PMID: 27223265 Free PMC article.
861 results