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Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Peters TL, Tillotson J, Yeomans AM, Wilmore S, Lemm E, Jiménez-Romero C, Amador LA, Li L, Amin AD, Pongtornpipat P, Zerio CJ, Ambrose AJ, Paine-Murrieta G, Greninger P, Vega F, Benes CH, Packham G, Rodríguez AD, Chapman E, Schatz JH. Peters TL, et al. Among authors: schatz jh. Clin Cancer Res. 2018 Sep 1;24(17):4256-4270. doi: 10.1158/1078-0432.CCR-17-3645. Epub 2018 May 29. Clin Cancer Res. 2018. PMID: 29844128 Free PMC article.
Kinase overexpressing cancers responsive to drug withdrawal.
Amin AD, Rajan SS, Schatz JH. Amin AD, et al. Among authors: schatz jh. Aging (Albany NY). 2015 Oct;7(10):752-3. doi: 10.18632/aging.100830. Aging (Albany NY). 2015. PMID: 26525633 Free PMC article. No abstract available.
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. Tillotson J, et al. Among authors: schatz jh. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. Bioorg Med Chem Lett. 2017. PMID: 28757063 Free PMC article.
eIF4A inhibition: ready for primetime?
Cunningham TA, Chapman E, Schatz JH. Cunningham TA, et al. Among authors: schatz jh. Oncotarget. 2018 Oct 30;9(85):35515-35516. doi: 10.18632/oncotarget.26268. eCollection 2018 Oct 30. Oncotarget. 2018. PMID: 30473746 Free PMC article. No abstract available.
55 results