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ROS, thiols and thiol-regulating systems in male gametogenesis.
Conrad M, Ingold I, Buday K, Kobayashi S, Angeli JP. Conrad M, et al. Biochim Biophys Acta. 2015 Aug;1850(8):1566-74. doi: 10.1016/j.bbagen.2014.10.020. Epub 2014 Oct 23. Biochim Biophys Acta. 2015. PMID: 25450170 Review.
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.
Hellfritsch J, Kirsch J, Schneider M, Fluege T, Wortmann M, Frijhoff J, Dagnell M, Fey T, Esposito I, Kölle P, Pogoda K, Angeli JP, Ingold I, Kuhlencordt P, Östman A, Pohl U, Conrad M, Beck H. Hellfritsch J, et al. Among authors: conrad m. Antioxid Redox Signal. 2015 Apr 10;22(11):938-50. doi: 10.1089/ars.2014.5889. Antioxid Redox Signal. 2015. PMID: 25647640 Free PMC article.
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Friedmann Angeli JP, Conrad M. Ingold I, et al. Among authors: conrad m. J Biol Chem. 2015 Jun 5;290(23):14668-78. doi: 10.1074/jbc.M115.656363. Epub 2015 Apr 28. J Biol Chem. 2015. PMID: 25922076 Free PMC article.
Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.
Holzerova E, Danhauser K, Haack TB, Kremer LS, Melcher M, Ingold I, Kobayashi S, Terrile C, Wolf P, Schaper J, Mayatepek E, Baertling F, Friedmann Angeli JP, Conrad M, Strom TM, Meitinger T, Prokisch H, Distelmaier F. Holzerova E, et al. Among authors: conrad m. Brain. 2016 Feb;139(Pt 2):346-54. doi: 10.1093/brain/awv350. Epub 2015 Dec 1. Brain. 2016. PMID: 26626369
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth.
Kim SE, Zhang L, Ma K, Riegman M, Chen F, Ingold I, Conrad M, Turker MZ, Gao M, Jiang X, Monette S, Pauliah M, Gonen M, Zanzonico P, Quinn T, Wiesner U, Bradbury MS, Overholtzer M. Kim SE, et al. Among authors: conrad m. Nat Nanotechnol. 2016 Nov;11(11):977-985. doi: 10.1038/nnano.2016.164. Epub 2016 Sep 26. Nat Nanotechnol. 2016. PMID: 27668796 Free PMC article.
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. Doll S, et al. Among authors: conrad m. Nat Chem Biol. 2017 Jan;13(1):91-98. doi: 10.1038/nchembio.2239. Epub 2016 Nov 14. Nat Chem Biol. 2017. PMID: 27842070 Free PMC article.
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M. Ingold I, et al. Among authors: conrad m. Cell. 2018 Jan 25;172(3):409-422.e21. doi: 10.1016/j.cell.2017.11.048. Epub 2017 Dec 28. Cell. 2018. PMID: 29290465 Free article.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T. Hassannia B, et al. Among authors: conrad m. J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29939160 Free PMC article.
1,335 results