Rathkey JK - Search Results

1

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Yang J, et al. Among authors: rathkey jk. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891674 Free PMC article.

2

Live-cell visualization of gasdermin D-driven pyroptotic cell death.

Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW. Rathkey JK, et al. J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18. J Biol Chem. 2017. PMID: 28726636 Free PMC article.

3

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

Liu Z, Wang C, Rathkey JK, Yang J, Dubyak GR, Abbott DW, Xiao TS. Liu Z, et al. Among authors: rathkey jk. Structure. 2018 May 1;26(5):778-784.e3. doi: 10.1016/j.str.2018.03.002. Epub 2018 Mar 22. Structure. 2018. PMID: 29576317 Free PMC article.

4

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Rathkey JK, et al. Sci Immunol. 2018 Aug 24;3(26):eaat2738. doi: 10.1126/sciimmunol.aat2738. Sci Immunol. 2018. PMID: 30143556 Free PMC article.

5

Human polymorphisms in GSDMD alter the inflammatory response.

Rathkey JK, Xiao TS, Abbott DW. Rathkey JK, et al. J Biol Chem. 2020 Mar 6;295(10):3228-3238. doi: 10.1074/jbc.RA119.010604. Epub 2020 Jan 27. J Biol Chem. 2020. PMID: 31988247 Free PMC article.

6

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides.

Russo HM, Rathkey J, Boyd-Tressler A, Katsnelson MA, Abbott DW, Dubyak GR. Russo HM, et al. J Immunol. 2016 Aug 15;197(4):1353-67. doi: 10.4049/jimmunol.1600699. Epub 2016 Jul 6. J Immunol. 2016. PMID: 27385778 Free PMC article.

7

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. Chirieleison SM, et al. Among authors: rathkey jk. J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. J Biol Chem. 2017. PMID: 28404814 Free PMC article.

8

Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity.

Chirieleison SM, Rathkey JK, Abbott DW. Chirieleison SM, et al. Among authors: rathkey jk. Sci Signal. 2018 Jul 17;11(539):eaao3964. doi: 10.1126/scisignal.aao3964. Sci Signal. 2018. PMID: 30018081 Free PMC article.

9

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis.

Karmakar M, Minns M, Greenberg EN, Diaz-Aponte J, Pestonjamasp K, Johnson JL, Rathkey JK, Abbott DW, Wang K, Shao F, Catz SD, Dubyak GR, Pearlman E. Karmakar M, et al. Among authors: rathkey jk. Nat Commun. 2020 May 5;11(1):2212. doi: 10.1038/s41467-020-16043-9. Nat Commun. 2020. PMID: 32371889 Free PMC article.

10

People choose to run at their optimal speed.

Rathkey JK, Wall-Scheffler CM. Rathkey JK, et al. Am J Phys Anthropol. 2017 May;163(1):85-93. doi: 10.1002/ajpa.23187. Epub 2017 Feb 14. Am J Phys Anthropol. 2017. PMID: 28195301

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