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Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.
Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng GS, Lu Z. Cheng J, et al. Among authors: chen b, chen s, chen g. FASEB J. 2017 Dec;31(12):5530-5542. doi: 10.1096/fj.201700120RR. Epub 2017 Aug 21. FASEB J. 2017. PMID: 28842424 Free PMC article.
IL-6 signaling was increased by Gab2 overexpression and impaired by Gab2 deletion via regulation of Jak2 and signal transducer and activator of transcription 3 phosphorylation and the expression of downstream genes, such as Bcl-2 (B-cell lymphoma 2), c-Myc, MMP7 (matrix metallopr …
IL-6 signaling was increased by Gab2 overexpression and impaired by Gab2 deletion via regulation of Jak2 and signal transducer and activator …
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