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Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4).
Frasinyuk MS, Zhang W, Wyrebek P, Yu T, Xu X, Sviripa VM, Bondarenko SP, Xie Y, Ngo HX, Morris AJ, Mohler JL, Fiandalo MV, Watt DS, Liu C. Frasinyuk MS, et al. Among authors: watt ds. Org Biomol Chem. 2017 Sep 20;15(36):7623-7629. doi: 10.1039/c7ob01584d. Org Biomol Chem. 2017. PMID: 28868548 Free PMC article.
Pictet-Spengler condensations using 4-(2-aminoethyl)coumarins.
Sviripa VM, Fiandalo MV, Begley KL, Wyrebek P, Kril LM, Balia AG, Parkin SR, Subramanian V, Chen X, Williams AH, Zhan CG, Liu C, Mohler JL, Watt DS. Sviripa VM, et al. Among authors: watt ds. New J Chem. 2020 Aug 21;44(31):13415-13429. doi: 10.1039/d0nj02664f. Epub 2020 Jul 22. New J Chem. 2020. PMID: 33795928 Free PMC article.
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Xie Y, Kril LM, Yu T, Zhang W, Frasinyuk MS, Bondarenko SP, Kondratyuk KM, Hausman E, Martin ZM, Wyrebek PP, Liu X, Deaciuc A, Dwoskin LP, Chen J, Zhu H, Zhan CG, Sviripa VM, Blackburn J, Watt DS, Liu C. Xie Y, et al. Among authors: watt ds. Sci Rep. 2019 Apr 23;9(1):6439. doi: 10.1038/s41598-019-42917-0. Sci Rep. 2019. PMID: 31015569 Free PMC article.
100 results