Somervaille TCP - Search Results

1

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Paredes R, Schneider M, Stevens A, White DJ, Williamson AJK, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, Somervaille TCP, Pierce A, Whetton AD, Meyer S. Paredes R, et al. Among authors: somervaille tcp. Nucleic Acids Res. 2018 Sep 6;46(15):7662-7674. doi: 10.1093/nar/gky536. Nucleic Acids Res. 2018. PMID: 29939287 Free PMC article.

2

MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.

Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V. Mascarenhas J, et al. Among authors: somervaille tcp. J Clin Oncol. 2023 Nov 10;41(32):4993-5004. doi: 10.1200/JCO.22.01972. Epub 2023 Mar 7. J Clin Oncol. 2023. PMID: 36881782 Free PMC article. Clinical Trial.

3

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S. White DJ, et al. PLoS One. 2013 Jun 12;8(6):e66510. doi: 10.1371/journal.pone.0066510. Print 2013. PLoS One. 2013. PMID: 23776681 Free PMC article.

4

The variety of leukemic stem cells in myeloid malignancy.

Wiseman DH, Greystoke BF, Somervaille TC. Wiseman DH, et al. Oncogene. 2014 Jun 12;33(24):3091-8. doi: 10.1038/onc.2013.269. Epub 2013 Jul 8. Oncogene. 2014. PMID: 23831573 Review.

5

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1.

Lynch JT, Cockerill MJ, Hitchin JR, Wiseman DH, Somervaille TC. Lynch JT, et al. Anal Biochem. 2013 Nov 1;442(1):104-6. doi: 10.1016/j.ab.2013.07.032. Epub 2013 Jul 31. Anal Biochem. 2013. PMID: 23911524

6

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.

Wiseman DH, Small HF, Wilks DP, Waddell ID, Dennis MW, Ogilvie DJ, Somervaille TC. Wiseman DH, et al. Br J Haematol. 2014 Jul;166(1):145-8. doi: 10.1111/bjh.12826. Epub 2014 Mar 10. Br J Haematol. 2014. PMID: 24606602 Free article. No abstract available.

7

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia.

Korfi K, Mandal A, Furney SJ, Wiseman D, Somervaille TCP, Marais R. Korfi K, et al. Among authors: somervaille tcp. Ann Oncol. 2015 Jun;26(6):1180-1187. doi: 10.1093/annonc/mdv110. Epub 2015 Feb 23. Ann Oncol. 2015. PMID: 25712455 Free PMC article.

8

Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy.

Wiseman DH, Struys EA, Wilks DP, Clark CI, Dennis MW, Jansen EE, Salomons GS, Somervaille TC. Wiseman DH, et al. Leukemia. 2015 Dec;29(12):2421-3. doi: 10.1038/leu.2015.151. Epub 2015 Jun 19. Leukemia. 2015. PMID: 26088953 No abstract available.

9

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

Somerville TD, Wiseman DH, Spencer GJ, Huang X, Lynch JT, Leong HS, Williams EL, Cheesman E, Somervaille TC. Somerville TD, et al. Cancer Cell. 2015 Sep 14;28(3):329-42. doi: 10.1016/j.ccell.2015.07.017. Cancer Cell. 2015. PMID: 26373280 Free article.

10

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia.

Wiseman DH, Williams EL, Wilks DP, Sun Leong H, Somerville TD, Dennis MW, Struys EA, Bakkali A, Salomons GS, Somervaille TC. Wiseman DH, et al. Leukemia. 2016 Sep;30(9):1946-50. doi: 10.1038/leu.2016.93. Epub 2016 Apr 27. Leukemia. 2016. PMID: 27118404 Free PMC article. No abstract available.

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