Morrow CJ - Search Results

1

The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.

Lallo A, Frese KK, Morrow CJ, Sloane R, Gulati S, Schenk MW, Trapani F, Simms N, Galvin M, Brown S, Hodgkinson CL, Priest L, Hughes A, Lai Z, Cadogan E, Khandelwal G, Simpson KL, Miller C, Blackhall F, O'Connor MJ, Dive C. Lallo A, et al. Among authors: morrow cj. Clin Cancer Res. 2018 Oct 15;24(20):5153-5164. doi: 10.1158/1078-0432.CCR-17-2805. Epub 2018 Jun 25. Clin Cancer Res. 2018. PMID: 29941481 Free article.

2

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

Morrow CJ, Gray A, Dive C. Morrow CJ, et al. FEBS Lett. 2005 Sep 26;579(23):5123-8. doi: 10.1016/j.febslet.2005.07.096. FEBS Lett. 2005. PMID: 16150444 Free article.

3

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.

Martin-Fernandez C, Bales J, Hodgkinson C, Welman A, Welham MJ, Dive C, Morrow CJ. Martin-Fernandez C, et al. Among authors: morrow cj. Mol Cancer Res. 2009 Jun;7(6):955-65. doi: 10.1158/1541-7786.MCR-08-0445. Epub 2009 Jun 9. Mol Cancer Res. 2009. PMID: 19509113 Free PMC article.

4

Src family kinase inhibitor Saracatinib (AZD0530) impairs oxaliplatin uptake in colorectal cancer cells and blocks organic cation transporters.

Morrow CJ, Ghattas M, Smith C, Bönisch H, Bryce RA, Hickinson DM, Green TP, Dive C. Morrow CJ, et al. Cancer Res. 2010 Jul 15;70(14):5931-41. doi: 10.1158/0008-5472.CAN-10-0694. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551056 Free PMC article.

5

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

Harrison LR, Micha D, Brandenburg M, Simpson KL, Morrow CJ, Denneny O, Hodgkinson C, Yunus Z, Dempsey C, Roberts D, Blackhall F, Makin G, Dive C. Harrison LR, et al. Among authors: morrow cj. J Clin Invest. 2011 Mar;121(3):1075-87. doi: 10.1172/JCI43505. J Clin Invest. 2011. PMID: 21393866 Free PMC article.

6

The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells.

Klymenko T, Brandenburg M, Morrow C, Dive C, Makin G. Klymenko T, et al. Mol Cancer Ther. 2011 Dec;10(12):2373-83. doi: 10.1158/1535-7163.MCT-11-0326. Epub 2011 Oct 17. Mol Cancer Ther. 2011. PMID: 22006676 Free PMC article.

7

[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941.

Cawthorne C, Burrows N, Gieling RG, Morrow CJ, Forster D, Gregory J, Radigois M, Smigova A, Babur M, Simpson K, Hodgkinson C, Brown G, McMahon A, Dive C, Hiscock D, Wilson I, Williams KJ. Cawthorne C, et al. Among authors: morrow cj. Mol Cancer Ther. 2013 May;12(5):819-28. doi: 10.1158/1535-7163.MCT-12-0905. Epub 2013 Feb 20. Mol Cancer Ther. 2013. PMID: 23427298 Free PMC article.

8

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.

Polański R, Hodgkinson CL, Fusi A, Nonaka D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE, Smith PD, Blackhall F, Dive C, Morrow CJ. Polański R, et al. Among authors: morrow cj. Clin Cancer Res. 2014 Feb 15;20(4):926-937. doi: 10.1158/1078-0432.CCR-13-2270. Epub 2013 Nov 25. Clin Cancer Res. 2014. PMID: 24277449 Free PMC article.

9

BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.

Potter DS, Kelly P, Denneny O, Juvin V, Stephens LR, Dive C, Morrow CJ. Potter DS, et al. Among authors: morrow cj. Neoplasia. 2014 Feb;16(2):147-57. doi: 10.1593/neo.131376. Neoplasia. 2014. PMID: 24709422 Free PMC article.

10

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.

Hodgkinson CL, Morrow CJ, Li Y, Metcalf RL, Rothwell DG, Trapani F, Polanski R, Burt DJ, Simpson KL, Morris K, Pepper SD, Nonaka D, Greystoke A, Kelly P, Bola B, Krebs MG, Antonello J, Ayub M, Faulkner S, Priest L, Carter L, Tate C, Miller CJ, Blackhall F, Brady G, Dive C. Hodgkinson CL, et al. Among authors: morrow cj. Nat Med. 2014 Aug;20(8):897-903. doi: 10.1038/nm.3600. Epub 2014 Jun 1. Nat Med. 2014. PMID: 24880617

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