Chávez-Gutiérrez L - Search Results

1

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium; Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Wiseman FK, et al. Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Brain. 2018. PMID: 29945247 Free PMC article.

2

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

Tolia A, Chávez-Gutiérrez L, De Strooper B. Tolia A, et al. J Biol Chem. 2006 Sep 15;281(37):27633-42. doi: 10.1074/jbc.M604997200. Epub 2006 Jul 14. J Biol Chem. 2006. PMID: 16844686 Free article.

3

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. Chávez-Gutiérrez L, et al. J Biol Chem. 2008 Jul 18;283(29):20096-105. doi: 10.1074/jbc.M803040200. Epub 2008 May 23. J Biol Chem. 2008. PMID: 18502756 Free article.

4

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Zhou L, et al. J Biol Chem. 2011 Mar 11;286(10):8677-8687. doi: 10.1074/jbc.M110.194860. Epub 2011 Jan 5. J Biol Chem. 2011. PMID: 21209097 Free PMC article.

5

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.

Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. Bammens L, et al. J Biol Chem. 2011 Apr 8;286(14):12271-82. doi: 10.1074/jbc.M110.216978. Epub 2011 Feb 4. J Biol Chem. 2011. Retraction in: J Biol Chem. 2023 Jul;299(7):104985. doi: 10.1016/j.jbc.2023.104985 PMID: 21296884 Free PMC article. Retracted.

6

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.

7

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B. Chávez-Gutiérrez L, et al. EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13. EMBO J. 2012. PMID: 22505025 Free PMC article.

8

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B. Acx H, et al. J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13. J Biol Chem. 2014. PMID: 24338474 Free PMC article.

9

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

De Strooper B, Chávez Gutiérrez L. De Strooper B, et al. Annu Rev Pharmacol Toxicol. 2015;55:419-37. doi: 10.1146/annurev-pharmtox-010814-124309. Epub 2014 Oct 1. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292430 Review.

10

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease.

Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, Revesz T, Lashley T, Fox NC. Ryan NS, et al. Neurobiol Aging. 2015 Dec;36(12):3140-3151. doi: 10.1016/j.neurobiolaging.2015.08.026. Epub 2015 Sep 4. Neurobiol Aging. 2015. PMID: 26410308

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

56 results

Search Page

Filters