Krishnan N - Search Results

1

DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease.

Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK. Krishnan N, et al. Genes Dev. 2018 Jul 1;32(13-14):944-952. doi: 10.1101/gad.314658.118. Epub 2018 Jun 26. Genes Dev. 2018. PMID: 29945887 Free PMC article.

2

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

Krishnan N, Konidaris KF, Gasser G, Tonks NK. Krishnan N, et al. J Biol Chem. 2018 Feb 2;293(5):1517-1525. doi: 10.1074/jbc.C117.819110. Epub 2017 Dec 7. J Biol Chem. 2018. PMID: 29217773 Free PMC article.

3

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Krishnan N, Fu C, Pappin DJ, Tonks NK. Krishnan N, et al. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. Sci Signal. 2011. PMID: 22169477 Free PMC article.

4

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases.

Krishnan N, Bencze G, Cohen P, Tonks NK. Krishnan N, et al. FEBS J. 2013 Jun;280(12):2830-41. doi: 10.1111/febs.12283. Epub 2013 May 9. FEBS J. 2013. PMID: 23578302 Free PMC article.

5

Anxious moments for the protein tyrosine phosphatase PTP1B.

Krishnan N, Tonks NK. Krishnan N, et al. Trends Neurosci. 2015 Aug;38(8):462-5. doi: 10.1016/j.tins.2015.06.006. Epub 2015 Jul 9. Trends Neurosci. 2015. PMID: 26166619 Free PMC article.

6

A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.

Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. Ramesh M, et al. Among authors: krishnan n. J Biol Chem. 2015 Apr 10;290(15):9646-59. doi: 10.1074/jbc.M114.627968. Epub 2015 Feb 13. J Biol Chem. 2015. PMID: 25681440 Free PMC article.

7

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.

Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ, Tonks NK. Krishnan N, et al. J Biol Chem. 2009 Jun 12;284(24):16066-16070. doi: 10.1074/jbc.C900032200. Epub 2009 Apr 7. J Biol Chem. 2009. PMID: 19351884 Free PMC article.

8

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.

Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Krishnan N, et al. Nat Chem Biol. 2014 Jul;10(7):558-66. doi: 10.1038/nchembio.1528. Epub 2014 May 20. Nat Chem Biol. 2014. PMID: 24845231 Free PMC article.

9

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1.

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK. Schwertassek U, et al. Among authors: krishnan n. FEBS J. 2014 Aug;281(16):3545-58. doi: 10.1111/febs.12898. Epub 2014 Jul 23. FEBS J. 2014. PMID: 24976139 Free PMC article.

10

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.

Krishnan N, Bonham CA, Rus IA, Shrestha OK, Gauss CM, Haque A, Tocilj A, Joshua-Tor L, Tonks NK. Krishnan N, et al. Nat Commun. 2018 Jan 18;9(1):283. doi: 10.1038/s41467-017-02252-2. Nat Commun. 2018. PMID: 29348454 Free PMC article.

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