Soto-Velasquez M - Search Results

1

A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling.

Soto-Velasquez M, Hayes MP, Alpsoy A, Dykhuizen EC, Watts VJ. Soto-Velasquez M, et al. Mol Pharmacol. 2018 Sep;94(3):963-972. doi: 10.1124/mol.118.111849. Epub 2018 Jun 27. Mol Pharmacol. 2018. PMID: 29950405 Free PMC article.

2

Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor.

Rana N, Conley JM, Soto-Velasquez M, León F, Cutler SJ, Watts VJ, Lill MA. Rana N, et al. J Chem Inf Model. 2017 Feb 27;57(2):322-334. doi: 10.1021/acs.jcim.6b00454. Epub 2017 Jan 26. J Chem Inf Model. 2017. PMID: 28068084

3

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. Brust TF, et al. Among authors: soto velasquez m. Sci Signal. 2017 Feb 21;10(467):eaah5381. doi: 10.1126/scisignal.aah5381. Sci Signal. 2017. PMID: 28223412 Free PMC article.

4

Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL. Hayes MP, et al. Among authors: soto velasquez m. ACS Chem Neurosci. 2018 Feb 21;9(2):346-357. doi: 10.1021/acschemneuro.7b00349. Epub 2017 Oct 16. ACS Chem Neurosci. 2018. PMID: 28968502 Free PMC article.

5

Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D₁ and D₂ Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening.

Doyle TB, Muntean BS, Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ. Doyle TB, et al. Among authors: soto velasquez m. Cells. 2019 Nov 19;8(11):1468. doi: 10.3390/cells8111468. Cells. 2019. PMID: 31752385 Free PMC article.

6

Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase.

Ding Z, Ejendal KFK, Soto-Velasquez M, Hayes MP, Santoro N, Larsen MJ, Watts VJ. Ding Z, et al. Among authors: soto velasquez m. J Pharmacol Exp Ther. 2020 Mar;372(3):267-276. doi: 10.1124/jpet.119.261255. Epub 2019 Dec 19. J Pharmacol Exp Ther. 2020. PMID: 31857349 Free PMC article.

7

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca²⁺/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.

Scott JA, Soto-Velasquez M, Hayes MP, LaVigne JE, Miller HR, Kaur J, Ejendal KFK, Watts VJ, Flaherty DP. Scott JA, et al. Among authors: soto velasquez m. J Med Chem. 2022 Mar 24;65(6):4667-4686. doi: 10.1021/acs.jmedchem.1c01759. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271288 Free PMC article.

8

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Kaur J, et al. Among authors: soto velasquez m. Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30472604 Free PMC article.

9

Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.

Česnek M, Skácel J, Jansa P, Dračínský M, Šmídková M, Mertlíková-Kaiserová H, Soto-Velasquez MP, Watts VJ, Janeba Z. Česnek M, et al. Among authors: soto velasquez mp. ChemMedChem. 2018 Sep 6;13(17):1779-1796. doi: 10.1002/cmdc.201800332. Epub 2018 Jul 31. ChemMedChem. 2018. PMID: 29968968 Free PMC article.

10

Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.

Břehová P, Chaloupecká E, Česnek M, Skácel J, Dračínský M, Tloušťová E, Mertlíková-Kaiserová H, Soto-Velasquez MP, Watts VJ, Janeba Z. Břehová P, et al. Among authors: soto velasquez mp. Eur J Med Chem. 2021 Oct 15;222:113581. doi: 10.1016/j.ejmech.2021.113581. Epub 2021 May 28. Eur J Med Chem. 2021. PMID: 34102377 Free PMC article.

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